Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Likelihood-Based Estimation of a Proportional-Hazard, Competing- Risk Model with Grouped Duration Data [PDF]
This short paper demonstrates two important results related to the estimation of competing-risk models under the proportional-hazards assumption with grouped duration data.
Mark Yuying An
core
Effect of a Clinical Evidence Technology on Patient Skin Disease Outcomes in Primary Care: A Cluster-Randomized Controlled Trial [PDF]
, 2018 Objective: Providers’ use of clinical evidence technologies (CETs) improves their diagnosis and treatment decisions. Despite these benefits, few studies have evaluated the impact of CETs on patient outcomes. Investigators evaluated the effect of one CET,
Burke, Marianne +1 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Marginal proportional hazards models for multivariate interval-censored data. [PDF]
Biometrika, 2023 Xu Y, Zeng D, Lin DY.
europepmc +1 more source
Goodness-of-fit tests for the frailty distribution in proportional hazards models with shared frailty. [PDF]
Frailty models account for the clustering present in grouped event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. The choice of a
Claeskens, Gerda +2 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Goodness-of-fit tests in proportional hazards models with random effects. [PDF]
Biom J, 2023 González-Manteiga W +2 more
europepmc +1 more source
Health and Residential Mobility in Later Life: A New Analytical Technique to Address an Old Problem [PDF]
For some time researchers have known that the relationship between health and the residential mobility of the elderly is not straight forward and changes with age.
Lynda M. Hayward
core
The Two-Way Proportional Hazards Model
Journal of the Royal Statistical Society Series B: Statistical Methodology, 2002 SummarySurvival analysis problems often involve dual timescales, most commonly calendar date and lifetime, the latter being the elapsed time since an initiating event such as a heart transplant. In our main example attention is focused on the hazard rate of ‘death’ as a function of calendar date.
openaire +2 more sources