Results 111 to 120 of about 328,188 (291)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Comparing of cox model and parametric models in analysis of effective factors on event time of neuropathy in patients with type 2 diabetes

Journal of Research in Medical Sciences, 2017
Background: Cox proportional hazard model is the most common method for analyzing the effects of several variables on survival time. However, under certain circumstances, parametric models give more precise estimates to analyze survival data than Cox ...
Sadegh Kargarian-Marvasti, Shahnaz Rimaz, Jamileh Abolghasemi, Iraj Heydari   +3 more
doaj   +1 more source

Marginal proportional hazards models for clustered interval-censored data with time-dependent covariates. [PDF]

Biometrics, 2023
Cook K, Lu W, Wang R.
europepmc   +1 more source

Nonparametric Regression in Proportional Hazards Models

JOURNAL OF THE JAPAN STATISTICAL SOCIETY, 2004
Summary: \textit{J. Fan} et al. [Ann. Stat. 25, No. 4, 1661--1690 (1997; Zbl 0890.62023)] considered two kinds of nonparametric estimators of the effects of the covariates in proportional hazards models. One of them has no parametric assumption on the baseline hazard function and is based on the integration of the estimated first order derivative of ...
openaire   +3 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Improving efficiency of fitting Cox proportional hazards models for time-to-event outcomes in genome-wide association studies (GWAS). [PDF]

Bioinform Adv, 2023
Gebski V, Silva SSM, Byth K, Jenkins A, Keech A.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Factors associated with 30-day drug-related emergency department re-attendance among methamphetamine users: a territory-wide retrospective study in Hong Kong

BMC Emergency Medicine
Background Methamphetamine use is associated with frequent emergency department (ED) utilization, but factors associated with drug-related ED re-attendance are understudied. We aimed to characterize the pattern of 30-day drug-related ED re-attendance and
Rex Pui Kin Lam, Chi Keung Chan, Man Li Tse, Eric Ho Yin Lau, Matthew Sik Hon Tsui, Sherry Kit Wa Chan, Timothy Hudson Rainer   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Statistical Inference for Cox Proportional Hazards Models with a Diverging Number of Covariates. [PDF]

Scand Stat Theory Appl, 2023
Xia L, Nan B, Li Y.
europepmc   +1 more source