Proportional Asymptotics of Piecewise Exponential Proportional Hazards Models
We study the flexible piecewise exponential model in a high dimensional setting where the number of covariates $p$ grows proportionally to the number of observations $n$ and under the hypothesis of random uncorrelated Gaussian designs. We prove rigorously that the optimal ridge penalized log-likelihood of the model converges in probability to the ...
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Variational Bayes for high-dimensional proportional hazards models with applications within gene expression. [PDF]
Bioinformatics, 2022 Komodromos M +4 more
europepmc +1 more source
Bayesian Analysis of Hazard Regression Models under Order Restrictions on Covariate Effects and Ageing [PDF]
, 2007 We propose Bayesian inference in hazard regression models where the baseline hazard is unknown, covariate effects are possibly age-varying (non-proportional), and there is multiplicative frailty with arbitrary distribution.
Bhattacharjee, Arnab +1 more
core +4 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Women´s wages and childbearing decisions: Evidence from Italy [PDF]
During the early 1990s, Italy became one of the first countries to reach lowest-low fertility. This was also a period in which women´s education and labour force participation increased. We analyze the role of women´s (potential) wages on their fertility
Arnstein Aassve +2 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A comparison of machine learning models and Cox proportional hazards models regarding their ability to predict the risk of gastrointestinal cancer based on metabolic syndrome and its components. [PDF]
Front Oncol, 2023 Tran TT +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Risk Factors of Microvascular Complications Among Type 2 Diabetic Patients Using Cox Proportional Hazards Models: A Cohort Study in Tabuk Saudi Arabia. [PDF]
J Multidiscip Healthc, 2022 Saiyed NS +8 more
europepmc +1 more source