Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Variational Bayes for high-dimensional proportional hazards models with applications within gene expression. [PDF]
Bioinformatics, 2022 Komodromos M +4 more
europepmc +1 more source
Proportional Asymptotics of Piecewise Exponential Proportional Hazards Models
We study the flexible piecewise exponential model in a high dimensional setting where the number of covariates $p$ grows proportionally to the number of observations $n$ and under the hypothesis of random uncorrelated Gaussian designs. We prove rigorously that the optimal ridge penalized log-likelihood of the model converges in probability to the ...
openaire +2 more sources
Performance of Cox proportional hazard models on recovering the ground truth of confounded exposure–response relationships for large‐molecule oncology drugs [PDF]
, 2022 Victor Poon, Dan Lü
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Women´s wages and childbearing decisions: Evidence from Italy [PDF]
During the early 1990s, Italy became one of the first countries to reach lowest-low fertility. This was also a period in which women´s education and labour force participation increased. We analyze the role of women´s (potential) wages on their fertility
Arnstein Aassve +2 more
core
A comparison of machine learning models and Cox proportional hazards models regarding their ability to predict the risk of gastrointestinal cancer based on metabolic syndrome and its components. [PDF]
Front Oncol, 2023 Tran TT +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Risk Factors of Microvascular Complications Among Type 2 Diabetic Patients Using Cox Proportional Hazards Models: A Cohort Study in Tabuk Saudi Arabia. [PDF]
J Multidiscip Healthc, 2022 Saiyed NS +8 more
europepmc +1 more source