Results 161 to 170 of about 748,596 (376)

Estimating long-term pollution exposure effects through inverse probability weighting methods with Cox proportional hazards models. [PDF]

open access: yesEnviron Epidemiol, 2020
Higbee JD   +8 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Properties and inference for proportional Hazard models

open access: yesRevista Colombiana de Estadística, 2013
We consider an arbitrary continuous cumulative distribution function F(x) with a probability density function f(x) = dF(x)/dx and hazard function h f(x)=f(x)/[1-F(x)]. We propose a new family of distributions, the so-called proportional hazard distribution-function, whose hazard function is proportional to h f(x).
MARTÍNEZ-FLÓREZ, GUILLERMO   +2 more
openaire   +4 more sources

Functional ANOVA modeling for proportional hazards regression [PDF]

open access: bronze, 2000
Jianhua Z. Huang   +3 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

A Comparison of the Polytomous Logistic Regression and Joint Cox Proportional Hazards Models for Evaluating Multiple Disease Subtypes in Prospective Cohort Studies

open access: yesCancer Epidemiology, Biomarkers and Prevention, 2013
X. Xue   +7 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

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