Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
PICBayes: Bayesian proportional hazards models for partly interval-censored data. [PDF]
Pan C, Cai B.
europepmc +1 more source
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
Absolute risk from double nested case-control designs: cause-specific proportional hazards models with and without augmented estimating equations. [PDF]
Lee M, Gail MH.
europepmc +1 more source
Hypothesis tests for stratified mark-specific proportional hazards models with missing covariates, with application to HIV vaccine efficacy trials. [PDF]
Sun Y, Qi L, Yang G, Gilbert PB.
europepmc +1 more source
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Shared and unshared exposure measurement error in occupational cohort studies and their effects on statistical inference in proportional hazards models. [PDF]
Hoffmann S +4 more
europepmc +1 more source
Attributable risk function in the proportional hazards model for censored time-to-event [PDF]
Ying Qing Chen
openalex +1 more source

