Results 81 to 90 of about 106,408 (283)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A direct method for the evaluation of lower and upper bound ratchet limits

, 2011
The calculation of the ratchet limit is often vital for the assessment of the design and integrity of components which are subject to cyclic loading. This work describes the addition of a lower bound calculation to the existing Linear Matching Method ...
Ure, James Michael, Chen, Haofeng, Li, Tianbai, Mackenzie, Donald, Tipping, James, Chen, Weihang   +5 more
core  

Multiaxial Fatigue Life Prediction of Metallic Materials Based on Critical Plane Method under Non-Proportional Loading

, 2017
The critical plane method is widely discussed because of its effectiveness for predicting the multiaxial fatigue life prediction of metallic materials under the non-proportional loading conditions.
Er Nian Zhao, Wei Lian Qu
core   +1 more source

Modelling of column base plate connections with plate stiffeners and non‐proportional loading

, 2023
Column base plate connections are used widely. Their design is currently codified by Eurocode 3, though with explicit consideration of only base plates without stiff eners and subjected to a proportional loading path.
Cantisani, G., Gaetano Cantisani, Gaetano Della Corte, Della Corte, G.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fatigue Crack Growth Under Non-proportional Loading

, 2012
Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2011Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2011Orantısız Yükleme Durumunda Yorulma Çatlak Büyümesi Özet Orantısız yükleme ...
Mutlu, Nait
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Thermomechanically coupled model for non-proportional loading in SMAS [PDF]

, 2016
In this work, a new 3D thermomechanically coupled phenomenological model is proposed for SMAs. SMA behavior is described through several strain mechanisms, each associated with its proper internal variables. Forward and reverse transformation are allowed
CHEMISKY, Yves, CHATZIGEORGIOU, George, CHATZIATHANASIOU, Dimitris, MERAGHNI, Fodil   +3 more
core   +1 more source