Results 71 to 80 of about 25,996 (287)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Reasoning, models, and images: behavioral measures and cortical activity

, 2003
The goal of this study was to investigate the neurocognitive processes of mental imagery in deductive reasoning. Behavioral studies yielded four sorts of verbal relations: (1) visuospatial relations that are easy to envisage both visually and spatially; (
Johnson Laird, PN, Knauff, Markus, Fangmeier, Thomas, Johnson-Laird, P., Knauff, M., Ruff, C., Fangmeier , T., Ruff, Christian C., Fangmeier, T, Ruff, CC, Knauff, M, Johnson-Laird, Philip N.   +11 more
core   +1 more source

Evaluating middle years students' proportional reasoning

, 2012
Proportional reasoning is a key aspect of numeracy that is not always developed naturally by students. Understanding the types of proportional reasoning that students apply to different problem types is a useful first step to identifying ways to support ...
Hilton, Annettte, Goos, Merrilyn, O'Brien, Mia, O'Brien, M, Hilton, G, Goos, M, Hilton, Geoff, Hilton, A, Dole, Shelley   +8 more
core   +1 more source

Supporting Proportional Reasoning Through Technology Integration in Mathematics Learning

Jurnal Kependidikan
This study aims to analyze the role of technology in facilitating the development of students' proportional reasoning skills in mathematics learning. This study used the systematic literature review method with a qualitative approach.
Ahmad Lutfi, Nurjanah Nurjanah, Bambang Avip Priatna Martadiputra, Al Jupri   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Using Ratio Tables to Encourage Proportional Reasoning

, 2010
\ud USING RATIO TABLES TO ENCOURAGE\ud PROPORTIONAL REASONING\ud by\ud ?? Rita M. Nutsch 2009\ud Master of Science in Mathematics Education\ud California State University, Chico\ud Fall 2009\ud It is essential that proportional reasoning is developed at ...
Nutsch, Rita M.
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Penalaran Proporsional Siswa SMP Kelas IX dalam Menyelesaikan Masalah Matematika ditinjau dari Gender

Kreano: Jurnal Matematika Kreatif-Inovatif, 2017
Penelitian ini merupakan penelitian kualitatif yang bertujuan untuk mendeskripsikan penalaran proporsional siswa smp laki-laki dan perempuan dalam menyelesaikan masalah matematika.
Defi Indah Permatasari
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The development of multiplicative thinking and proportional reasoning: Models of conceptual learning and transfer

, 2012
This thesis considers the development of multiplicative thinking and proportional reasoning from two perspectives. Firstly, it examines the research literature on progressions in conceptual understanding to create a Hypothetical Learning Trajectory (HLT).
Wright, Vincent John
core