Results 51 to 60 of about 25,996 (287)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Preschoolers’ Selfish Sharing Is Reduced by Prior Experience With Proportional Generosity [PDF]

Open Mind, 2017
Young children make sophisticated social and normative inferences based on proportional reasoning. We explored the possibility that proportional cues also help children learn from and about their own generosity. Across two experiments,
Nadia Chernyak, Bertilia Y. Trieu, Tamar Kushnir   +2 more
doaj   +1 more source

Preservice Teachers’ Reflections on the Use of Visual Supports to Improve Mathematics Pedagogy

Journal of Mathematics Education at Teachers College, 2023
This case study inspected mathematical learning opportunities that employed the results from the participating preservice teachers’ (n=75) original visual arts creation process.
Song An, Daniel Tillman, Karime Smith, Alyse Hachey   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The relationship between proportional vocabulary and proportional reasoning abilities in young children

, 2023
Supplementary materials related to 'the relationship between proportional vocabulary and proportional reasoning abilities in young ...
Karen De Keersmaeker
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Enhancing Cognitive Flexibility Through a Training Based on Multiple Categorization: Developing Proportional Reasoning in Primary School

Journal of Numerical Cognition, 2022
Proportional reasoning is a key topic both at school and in everyday life. However, students are often misled by their preconceptions regarding proportions.
Calliste Scheibling-Sève, Katarina Gvozdic, Elena Pasquinelli, Emmanuel Sander   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Proportional Reasoning as Essential Numeracy [PDF]

, 2015
This paper reports an aspect of a large research and development project that aimed to promote middle years school teachers’ understanding and awareness of the pervasiveness of proportional reasoning as integral to numeracy.
Hilton, G, Hilton, Geoff, Dole, S, Hilton, A, Dole, Shelley, Hilton, Annette   +5 more
core