Results 91 to 100 of about 984,703 (281)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Polyakov loop at next-to-next-to leading order

, 2015
We calculate the next-to-next-to-leading correction to the expectation value of the Polyakov loop or equivalently to the free energy of a static charge. This correction is of order $g^5$. We show that up to this order the free energy of the static charge
Berwein, Matthias, Brambilla, Nora, Petreczky, Peter, Vairo, Antonio   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Redistribution and Reelection under Proportional Representation: The Postwar Italian Chamber of Deputies [PDF]

We study incumbency advantage and the electoral returns to pork and patronage over ten legislative periods from 1948 to 1992 for two political parties — the Christian Democrats (DC) and the Italian Socialist Party (PSI) — in Italy’s lower house of ...
Golden, Miriam, Picci, Lucio
core   +1 more source

Effects of cumpulsory voting on visible minority representation [PDF]

, 2015
This thesis examines the effects of compulsory voting on visible minority representation in directly elected legislatures with proportional electoral systems.
Schwartz, Belinda
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Municipal election systems and their implications for ethical and accountable democratic governance at eThekwini Municipality

Journal of Local Government Research and Innovation
Background: The electoral systems adopted for local government offer the citizens the democratic opportunity to elect their representatives through a proportional representative system and constituency electoral system.
Ndwakhulu S. Tshishonga
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Proportionality or majoritarianism? In search of electoral equity

Bajo Palabra, 2016
Finding an electoral system both equitable and efficient represents a desideratum for every electoral democracy. The electoral system is at the cornerstone of democracy and has important consequences upon the constitutional and political system as a ...
Elena Cincea
doaj