Results 61 to 70 of about 984,831 (324)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
A Vote Cast; A Vote Counted: Quantifying Voting Rights through Proportional Representation in Congressional Elections [PDF]
, 2002 The current winner-take-all or first-past-the-post system of voting promotes an inefficient market where votes are often wasted. In this system, representatives are selected from a single district in which the candidate with the plurality of votes gains ...
McCann, Michael
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
How do Electoral Systems Affect Fiscal Policy? Evidence from State and Local Governments, 1890 to 2005 [PDF]
Using a new data set on Swiss state and local governments from 1890 to today, we analyze how the adoption of proportional representation affects fiscal policy. We show that proportional systems shift spending toward broad goods (e.g.
Christina Gathmann, Patricia Funk
core
Graded KMS Functionals and the Breakdown of Supersymmetry [PDF]
, 1999 It is shown that the modulus of any graded or, more generally, twisted KMS functional of a C*-dynamical system is proportional to an ordinary KMS state and the twist is weakly inner in the corresponding GNS-representation.
Buchholz, Detlev, Longo, Roberto
core +5 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Some results on strategic voting and proportional representation with multidimensional policy space. [PDF]
We study a model of proportional representation, in which the policy space is multidimensional. We first show, via an example, that the assumption of quasi-concavity of the utility function is not sufficient to obtain the result that only the extreme ...
De Sinopoli, Francesco +1 more
core +3 more sources
Electoral Reform in Romania. An Analytical History (2)
Sfera Politicii, 2012 The paper seeks to retrace the electoral journey of modern Romania, highlighting the general synchronization procces of democratization of the vote, as well as the changes that occured in the practice of parliamentary election patterns.
Alexandru Radu
doaj
Extreme voting under proportional representation: the multidimensional case. [PDF]
We study the strategic behavior of voters in a model of proportional representation, in which the policy space is multidimensional. Our main finding is that in large electorate, under some assumptions on voters' preferences, voters essentially vote, in ...
De Sinopoli, Francesco +1 more
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source