Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
A study of Chinese law on restricting personal liberty for public health protection: taking the COVID-19 epidemic as the entry point. [PDF]
Liu T, Ma Z.
europepmc +1 more source
Enhancing Data Protection and Data Processing in the Public Sector:The Critical Role of Proportionality and the Public Interest [PDF]
Black, Gillian, Stevens, Leslie
core +1 more source
xx xx. ABSTRACT Stimuli‐responsive nanomaterials capable of spatiotemporal control over drug release are of nanocomposite patch (“e‐Medi‐Patch”) engineered from biodegradable polycaprolactone (PCL), graphene nanoplatelets, and a redox‐active therapeutic, niclosamide. The hierarchical composite integrates π‐π interactions between aromatic drug molecules
Santosh K. Misra +7 more
wiley +1 more source
Struggling over recognition: Honneth, political resistance, and violence. [PDF]
Pilapil RD.
europepmc +1 more source
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang +8 more
wiley +1 more source
Ethical Challenges in Care for Nursing Home Residents During COVID-19: Insights From a Qualitative Study. [PDF]
Aasmul I, Jacobsen FF.
europepmc +1 more source
Nonlocal Conduction in a Metawire
A 1D metawire composed of twisted copper wires is designed and realized. This metamaterial exhibits pronounced effects of nonlocal electric conduction according to Ohm's law. The current at one location not only depends on the electric field at that location but also on other locations.
Julio Andrés Iglesias Martínez +3 more
wiley +1 more source
Between Protection and Destruction: The Legal Tension Between Military Necessity and Cultural Heritage Protection in International Humanitarian Law. [PDF]
El Baroudy J, Albakjaji M, Khater M.
europepmc +1 more source
Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong +12 more
wiley +1 more source

