Results 91 to 100 of about 1,238,778 (293)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Stoichiometry of equations through the Inverse de Donder relation
Chemistry Teacher International, 2018 The stoichiometry of equations was revisited in light of the Law of Conservation of Matter at an atomic, elemental level. For a balanced chemical equation following the simplest general model aA → bB, the fact that ab=nAnB${a \over b} = {{{n_A}} \over ...
Mousavi Aliyar
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
DECISION-MAKING PROCESS BASED ON GROUP COLLABORATION: THE CASE OF TEACHING PROPORTIONS IN GRADE 7
Tạp chí Khoa họcIn the current context of educational reform, fostering students’ collaborative problem-solving skills and critical thinking through mathematics education has become an essential objective.
Do Van Chung, Thai Thi Hong Lam
doaj +1 more source
Design Scheme and Proportional Analysis of the Kufic Inscription on the Stone Mihrab of Turan Posht Mosque and Pilgrimage Site, Yazd [PDF]
پیکرهIntroduction: The Mosque and Pilgrimage Site of Turan Posht has a stone mihrab currently preserved in the Freer Gallery of Art in the United States. This stone mihrab features inscriptions in Kufic and Thuluth scripts. Based on the date inscribed on this
Sahar Salehi +3 more
doaj +1 more source
Structured proportional representation
Theoretical Computer Science, 2017 Multi-winner voting rules aiming at proportional representation, such as those suggested by Chamberlin and Courant and by Monroe, partition an electorate into virtual districts, such that a representative is assigned to each district; these districts are formed based on the voters' preferences.
openaire +2 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
The Use of Indices in Surveys [PDF]
The paper deals with some new indices for ordinal data that arise from sample surveys. Their aim is to measure the degree of concentration to the “positive” or “negative” answers in a given question. The properties of these indices are examined. Moreover,
Perakis, Michael +3 more
core
Maxillofacial Plastic and Reconstructive Surgery, 2018 Background In the absence of clear guidelines for facial aesthetic surgery, most surgeons rely on expert intuitive judgement when planning aesthetic and reconstructive surgery.
Angelos Mantelakis +6 more
doaj +1 more source