Results 81 to 90 of about 1,238,778 (293)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Types of Pottery from the Novoslavka-2 Burial Ground

Археология евразийских степей
We present the results of the preliminary study of pottery obtained during 4-year studies at the Novoslavка-2 burial ground. Dated to 450-550 AD based on artifact analysis, this burial ground belongs to the Komintern type of the Imenkovo culture.
Renat R. Valiev, Anna A. Kuklina
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Proportions, Harmonie et Beauté chez Mersenne

, 2008
Conférence donnée dans le cadre du colloque « Proportions », 51e colloque international d’études humanistes, Centre d’Etudes Supérieures de la Renaissance, Tours, 30 juin au 4 juillet ...
Proportions (51e colloque international d’études humanistes, Centre d’Études Supérieures de la Renaissance, Tours), Van Wymeersch, Brigitte   +1 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Logical proportions - Further investigations

, 2012
Logical proportions may be viewed as a Boolean counterpart of the notion of numerical proportions. They relate two pairs of binary variables, say (a,b) and (c, d), by stating the conjunction of two equivalences between similarity or dissimilarity ...
Prade, Henri, Richard, Gilles, Richard, G, Henri Prade, Gilles Richard, Prade, H   +5 more
core   +1 more source

Sample size estimation and power analysis for clinical research studies

Journal of Human Reproductive Sciences, 2012
Determining the optimal sample size for a study assures an adequate power to detect statistical significance. Hence, it is a critical step in the design of a planned research protocol.
K P Suresh, S Chandrashekara
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Recognition of Geometrical and Proportional Principles in Open and Semi-Open Spaces of Hot and Humid Climate (Case Study: Historical Houses of Bushehr) [PDF]

توسعه پایدار شهری
Proportion is one of the significant design principles featured in Iranian architecture. Several factors are influential in applying a certain type of spatial proportions. Climate and ecology are the most important ones.
Neda Naseri, Jamshid Davtalab, Faramarz Hassan Pour, Abolfazl Heidari, Zohreh Oveisi Keikha   +4 more
doaj   +1 more source