Results 141 to 150 of about 111,297 (312)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Substituição do carvedilol pelo propranolol em pacientes com insuficiência cardíaca Sustitución del carvedilol por el propranolol en pacientes con insuficiencia cardíaca Replacement of carvedilol for propranolol in patients with heart failure

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: Grandes estudos clínicos empregando os betabloqueadores carvedilol, metoprolol, bisoprolol e nebivolol, demonstraram melhora da sobrevida e dos sintomas em pacientes com insuficiência cardíaca.
Fabiana Marques, Renato Barroso Pereira de Castro, Fernando Nobre, Antonio Osvaldo Pintya, Lourenço Gallo Júnior, Benedito Carlos Maciel, Marcus Vinícius Simões   +6 more
doaj  

Propranolol for severe hemangiomas of infancy.

New England Journal of Medicine, 2008
C. Léauté-Labrèze, E. Dumas de la Roque, T. Hubiche, F. Boralevi, J. Thambo, A. Taïeb   +5 more
semanticscholar   +1 more source

[Toxicokinetiek van propranolol enantiomeren na een enkelvoudige intraveneuze dosis van racemisch propranolol in de rat.]

, 2012
niet beschikbaarConscious male Wistar SPF Riv: TOX rats, body weight 275-300 g, were dosed intravenously with 2.5, 5 or 10 mg/kg racemic propranolol. HCl and plasma disposition of both S-(-)-propranolol and R-(+)-propranolol was followed for three hours.
Arens ABM, Wemer J, Toet AE, Beenen J, Stolker AAM, Ginkel LA van, Poelen MJ, Groen C, Bode W, Wildt DJ de   +9 more
core  

Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol

, 2016
A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life ...
Favre C., Calvani M., Filippi L., Della Bona M. L., Defilippi C., Perrone A., la Marca G., Berti E., Tamburini A., Donzelli G.   +9 more
core   +1 more source

Mechanisms reducing parasympathetic activity in chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. Using β‐adrenergic blockade to isolate parasympathetic control of heart rate at sea level and after 9‐12 days at high altitude, we investigated whether (i) chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii ...
Lauren E. Maier, Andrew Douglas, Katharine Foster, Elliott J. Jenkins, Liam D. Corr, Peter Rasmussen, James Anholm, Travis D. Gibbons, Phil N. Ainslie, Mike Stembridge, Christoph Siebenmann   +10 more
wiley   +1 more source

The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran

, 2017
Introduction : Cyclic vomiting syndrome is a functional disorder characterised by repeated episodes of nausea and vomiting with symptom-free intervals between the attacks.
Naser Honar, Hajar Memari, Mohammad-Hadi Imanieh, Seyed Mohsen Dehghani, Seyed-Javad Injoo, Hazhir Javaherizadeh, Mahmoud Haghighat   +6 more
core   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Severe Diarrhea Secondary to Propranolol

, 1981
Although propranolol is effective and widely used for many disorders, there are reports of it causing side effects severe enough to warrant its discontinuance. A 71-year-old female is reported to have experienced diarrhea and weight loss from the use of
David E. Burtner, J. Daniel Robinson
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source