Results 41 to 50 of about 96,658 (272)

Propranolol suppresses the proliferation and induces the apoptosis of liver cancer cells

Molecular Medicine Reports, 2018
An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated.
Fang Wang, Hui Liu, Fengmei Wang, Ruicheng Xu, Peng Wang, Fei Tang, Xu Zhang, Zhengyan Zhu, Hongmin Lv, T. Han   +9 more
semanticscholar   +1 more source

Propranolol in Treatment of Huge and Complicated Infantile Hemangiomas in Egyptian Children

Dermatology Research and Practice, 2014
Background. Infantile hemangiomas (IHs) are the most common benign tumours of infancy. Propranolol has recently been reported to be a highly effective treatment for IHs.
Basheir A. Hassan, Khalid S. Shreef
doaj   +1 more source

Deep coma in a child treated with propranolol for infantile hemangioma

BMC Pediatrics, 2019
Background Propranolol hydrochloride is the first-line agent recommended for the treatment of infantile hemangiomas (IH). Serious adverse effects of propranolol therapy for hemangiomas are infrequent.
Ilirjana Bakalli, Elmira Kola, Robert Lluka, Ermela Celaj, Durim Sala, Inva Gjeta, Sashenka Sallabanda, Dea Klironomi   +7 more
doaj   +1 more source

Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis

Journal of Psychopharmacology, 2016
The effects of propranolol in the treatment of anxiety disorders have not been systematically evaluated previously. The aim was to conduct a systematic review and meta-analysis of randomised controlled trials, addressing the efficacy of oral propranolol ...
Serge A. Steenen, A. V. van Wijk, G. J. van der Heijden, Roos van Westrhenen, J. de Lange, A. de Jongh   +5 more
semanticscholar   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension—evidence from the APPROPRIATE trial

BMC Research Notes, 2020
Objectives The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial.
H. N. Ranasinghe, N. Fernando, S. Handunnetti, P. N. Weeratunga, P. Katulanda, S. Rajapakse, P. Galappatthy, G. R. Constantine   +7 more
doaj   +1 more source

Propranolol therapy for infantile hemangioma: our experience

Drug Design, Development and Therapy, 2017
Objective Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a ...
Ling Zhang, H. Wu, Wei-En Yuan, Jia-wei Zheng   +3 more
semanticscholar   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Perbandingan Efektivitas dan Keamanan Ligasi dengan atau Tanpa Propranolol pada Anak dengan Hipertensi Portal

Sari Pediatri
Latar belakang. Hipertensi portal (HP) didefinisikan sebagai peningkatan tekanan portal >5 mmHg, jika >12 mmHg dapat terjadi perdarahan saluran cerna.
Kadim Muzal, Amrina Rasyada
doaj   +1 more source