Results 31 to 40 of about 111,297 (312)

Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Scientific Reports, 2022
Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- and middle-income countries.
Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona   +7 more
doaj   +1 more source

Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial

Clinical Cancer Research, 2019
Purpose: The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β-blockers in preclinical studies.
J. Hiller, S. Cole, Elizabeth M. Crone, D. Byrne, David M. Shackleford, J. Pang, M. Henderson, S. Nightingale, K. Ho, P. Myles, S. Fox, B. Riedel, E. Sloan   +12 more
semanticscholar   +1 more source

Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride [PDF]

, 2006
A novel oral controlled delivery system for propranolol hydrochloride (PPL) was developed and optimized. The in vitro dissolution profiles of sustained-release matrix tablets of racemic PPL were determined and compared with the United States Pharmacopeia
Pedraz, José Luis, Bataille, Bernard, Iraizoz Colarte, Antonio, Rodriguez, Fernand, Castellanos Gil, Eddy, Heinämäki, Jyrki   +5 more
core   +1 more source

Efficacy of Combined Topical Timolol and Oral Propranolol for Treating Infantile Hemangioma: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2020
BackgroundOral propranolol has become the first-line treatment for infantile hemangioma (IH). However, combined therapy with topical timolol and oral propranolol has been proposed as a more effective IH treatment strategy.
Junbo Qiao, Junjie Lin, Dexin Zhang, Junhua Li, Changkuan Chen, Hongye Yu, Xiaodi Li, Bin Fang   +7 more
doaj   +1 more source

Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study

Frontiers in Pediatrics, 2019
Background: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated.Methods: A multi ...
Luca Filippi, Giacomo Cavallaro, Lavinia Perciasepe, Elena Sandini, Gabriella Araimo, Giulia Regiroli, Giulia Regiroli, Genny Raffaeli, Paola Bagnoli, Massimo Dal Monte, Maura Calvani, Pina Fortunato, Silvia Osnaghi, Salvatore De Masi, Fabio Mosca, Fabio Mosca   +15 more
doaj   +1 more source

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Frontiers in Oncology, 2021
Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance.
Jhuma Saha, Jong Hyuk Kim, Jong Hyuk Kim, Jong Hyuk Kim, Clarissa N. Amaya, Clarissa N. Amaya, Caleb Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Brad A. Bryan, Erin B. Dickerson, Erin B. Dickerson, Erin B. Dickerson   +15 more
doaj   +1 more source

The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study.

PLoS ONE, 2019
BackgroundBeta-blockers can reduce recurrence, metastasis, and mortality in various cancers. In this study, we investigated the effect of propranolol, a non-selective beta-blocker on overall survival (OS) in unresectable/metastatic hepatocellular ...
Ping-Ying Chang, Chi-Hsiang Chung, Wei-Chou Chang, Chun-Shu Lin, Hsuan-Hwai Lin, Ming-Shen Dai, Ching-Liang Ho, Wu-Chien Chien   +7 more
doaj   +1 more source

Splanchnic Venous Compression Enhances the Effects of ß‐Blockade in the Treatment of Postural Tachycardia Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Splanchnic venous pooling induced by upright posture triggers a compensatory increase in heart rate (HR), a response that is exaggerated in patients with postural tachycardia syndrome.
Emily C. Smith, André Diedrich, Satish R. Raj, Alfredo Gamboa, Cyndya A. Shibao, Bonnie K. Black, Amanda Peltier, Sachin Y. Paranjape, Italo Biaggioni, Luis E. Okamoto   +9 more
doaj   +1 more source

Combinative effects of β-elemene and propranolol on the proliferation, migration, and angiogenesis of hemangioma [PDF]

PeerJ, 2023
Hemangioma (HA) is one of the most common benign vascular tumors among children. Propranolol is used as the first-line treatment for hemangioma and is a non-selective blocker of the β-adrenergic receptor.
Zhenyu Wang, Yinxian Chen, Lin Yang, Dunbiao Yao, Yang Shen   +4 more
doaj   +2 more sources

Risk Factors for Airway Infantile Hemangioma. [PDF]

Acta Paediatr
ABSTRACT Aim An infantile hemangioma (IH) affecting the airway is rare. Identifying infants at risk for an airway IH is crucial to avoid potential airway compromise. Our objective was to identify risk factors for an airway IH and to study its incidence and treatments.
Castrén E, Salminen P, Kyrklund K.
europepmc   +2 more sources