Results 31 to 40 of about 18,216,246 (286)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Numerical and experimental investigation on the flow-rate stabilization features of a novel flow control valve design for variable-thrust spacecraft engine

Journal of Engineering and Applied Science
Precise modulation of propellant flow is crucial for thrust control in variable-thrust liquid rocket propulsion systems. This study presents investigations on a novel passive Pressure-Compensated Flow Control Valve (PCFCV) featuring a self-adjusting ...
Chinmoy Mondal, M. V. V. S. Kishore, Benoy Joseph K, Deepak Kumar Agarwal, Somnath Roy   +4 more
doaj   +1 more source

Leakage Flow Characteristics of Novel Two-Stage Brush Seal with Pressure-Equalizing Hole

Lubricants
Uneven inter-stage pressure drops of the common two-stage brush seal (CBS) lead to a problem that the second stage bristles bear excessive pressure load, and this problem leads to the premature failure of the brush seal.
Yu Li, Huanze Xu, Jinghan Zhang, Dan Sun, Zemin Yang   +4 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Displaced geostationary orbits using hybrid low-thrust propulsion [PDF]

, 2012
In this paper, displaced geostationary orbits using hybrid low-thrust propulsion, a complementary combination of Solar Electric Propulsion (SEP) and solar sailing, are investigated to increase the capacity of the geostationary ring that is starting to ...
Biggs, James, Jeannette Heiligers, BIGGS, JAMES DOUGLAS, Heiligers, Jeannette, McInnes, Colin, Ceriotti, Matteo, Heiligers, J., Ceriotti, M., Mcinnes, Colin R., Biggs, J.D., Colin R. McInnes, James D. Biggs, Matteo Ceriotti, McInnes, C.R.   +13 more
core   +3 more sources

A study on the development of job training curriculum for operation of electric propulsion ships

Journal of International Maritime Safety, Environmental Affairs, and Shipping, 2022
In order to reduce the emission of pollutants from ships, the need to introduce eco-friendly ships is gradually increasing. Recently built ships are being applied with eco-friendly ship propulsion systems that can replace the existing propulsion systems.
Hyeonmin Jeon, Jaejung Hur, Jongyoung Chun, Jongsu Kim   +3 more
doaj   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source