Results 31 to 40 of about 12,267,792 (308)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Techno-economic and environmental risk assessment of a turbo-electric distributed propulsion system on a blended wing body aircraft [PDF]

, 2014
Constant rise of air traffic has caused the environmental impacts of aviation to be the subject of an unprecedented scrutiny. Organisations all over the world are setting targets for emission reductions that represent the technological potential for ...
Giakoumakis, Eleftherios
core  

Influence of Circumferential Convergent Wedge Pocket on the Segmented Annular Seal’s Static and Dynamic Characteristics

Lubricants
Aiming at the problem of abnormal wear caused by the poor dynamic characteristics of aeroengine segmented annular seals, according to the hydrodynamic lubrication theory, based on the conventional structure featuring the Rayleigh step profile rectangular
Shuang Wang, Dan Sun, Zemin Yang, Wenfeng Xu, Huan Zhao   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Arcjet Propulsion System Study for NSSK [PDF]

, 1993
The study of a low power arcjet propulsion system and its application to north-south .station keeping of geostationary telecommunication satellites was carried out at Centrospazio in the framework of the arcjet propulsion system development program ...
ANDRENUCCI, MARIANO, D'AGOSTINO, LUCA, D'AURIA F, SCORTECCI F   +3 more
core  

Multi-Domain Entropy-Random Forest Method for the Fusion Diagnosis of Inter-Shaft Bearing Faults with Acoustic Emission Signals

Entropy, 2019
Inter-shaft bearing as a key component of turbomachinery is a major source of catastrophic accidents. Due to the requirement of high sampling frequency and high sensitivity to impact signals, AE (Acoustic Emission) signals are widely applied to monitor ...
Jing Tian, Lili Liu, Fengling Zhang, Yanting Ai, Rui Wang, Chengwei Fei   +5 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Numerical and experimental investigation on the flow-rate stabilization features of a novel flow control valve design for variable-thrust spacecraft engine

Journal of Engineering and Applied Science
Precise modulation of propellant flow is crucial for thrust control in variable-thrust liquid rocket propulsion systems. This study presents investigations on a novel passive Pressure-Compensated Flow Control Valve (PCFCV) featuring a self-adjusting ...
Chinmoy Mondal, M. V. V. S. Kishore, Benoy Joseph K, Deepak Kumar Agarwal, Somnath Roy   +4 more
doaj   +1 more source

Leakage Flow Characteristics of Novel Two-Stage Brush Seal with Pressure-Equalizing Hole

Lubricants
Uneven inter-stage pressure drops of the common two-stage brush seal (CBS) lead to a problem that the second stage bristles bear excessive pressure load, and this problem leads to the premature failure of the brush seal.
Yu Li, Huanze Xu, Jinghan Zhang, Dan Sun, Zemin Yang   +4 more
doaj   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source