Results 121 to 130 of about 69,603 (339)
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Advanced Science, EarlyView.This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue +13 more
wiley +1 more source
Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells
Advanced Science, EarlyView.Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li +8 more
wiley +1 more source
Frequency Modulation Technique for Prosodic Modification [PDF]
, 2008 Jinfu Ni +3 more
openalex +1 more source
Advanced Science, EarlyView.Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi +5 more
wiley +1 more source
Supramolecular Phase Change Materials for Spatiotemporally Thermal Energy Utilization
Advanced Science, EarlyView.The long‐term storage as well as switchable and controllable release of thermal energy using activated perethylated pillar[5]arene EtP5 (EtP5α) is demonstrated for the first time. High thermal energy storage capacity can be maintained over 20 thermal cycles and for more than 365 days at room temperature, which is the PCMs that can store thermal energy ...
Miaomiao Yan +5 more
wiley +1 more source
AI‐Optimized Vanadium Oxide Multilayers for More Than 20‐fold Enhancement in Bolometric Performance
Advanced Science, EarlyView.Machine‐learning‐optimized WxV1‐xOy multilayer thin films with graded doping achieve a high TCR (7.3 % K−1), reduced hysteresis, and low noise under CMOS‐compatible growth conditions. This approach overcomes the long‐standing trade‐off in microbolometers between linear response and performance, offering a universal bolometric parameter greatly enhanced
Jin‐Hyun Choi +8 more
wiley +1 more source
Brain SciencesBackground/Objectives: Emotional prosody, the intonation and rhythm of speech that conveys emotions, is vital for speech communication as it provides essential context and nuance to the words being spoken.
Chieh Kao, Yang Zhang
doaj +1 more source
Advanced Science, EarlyView.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
Carrot and stick 2.0: The benefits of natural and motivational prosody in computer-assisted learning
, 2014 Susann Wolff, Norman Peitek
openalex +1 more source