Results 191 to 200 of about 827,645 (268)

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Protocol for a Prospective Cohort Study on Determinants of Outcomes in Lumbar Radiculopathy Surgery. [PDF]

Healthcare (Basel)
Aceituno-Rodríguez A, Bustamante C, Rodríguez-Rivera C, Molina-Álvarez M, Rodríguez-Moro C, García-Cañas R, Goicoechea C, Matesanz-García L.   +7 more
europepmc   +1 more source

Multicentre online registration of bronchopulmonary dysplasia in very preterm infants in China: protocol for a prospective, open, observational cohort study

Shengnan He, Haibo Peng, Ping Zhou, Fei Hu, Xudong Yan, Qian Su, Boshi Yu, Yuqi Li, Cheng Chen, Xin Guo, Ying Liu, Yanping Guo, Jiebo Liu, Dan Dan Rao, Lian Zhang, Zhangbin Yu   +15 more
openalex   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Compliance of Tonsillitis e-Health Patients: A Prospective Cohort Study. [PDF]

Laryngoscope Investig Otolaryngol
Hakanen O, Lamminmäki S, Torkki P, Tolvi M.   +3 more
europepmc   +1 more source

Tumor‐Informed ctDNA in Guiding First‐Line Immunochemotherapy in Advanced Non‐Small Cell Lung Cancers

Advanced Science, EarlyView.
Tumor‐informed circulating tumor DNA (ctDNA) analysis identifies patients with advanced non‐small cell lung cancer (NSCLC) who benefit from first‐line immunotherapy plus chemotherapy. Longitudinal ctDNA monitoring further reflects therapeutic response and predicts prognosis beyond imaging.
Kailun Fei, Jie Zhao, Jiachen Xu, Jianchun Duan, Chengcheng Li, Wenchuan Xie, Jia Zhong, Guoqiang Wang, Yu Xu, Boyang Sun, Rui Wan, Hua Bai, Qinxiang Guo, Wei Guo, Shangli Cai, Zhijie Wang, Jie Wang   +16 more
wiley   +1 more source

Prophylactic mesh reinforcement after open aortic aneurysm repair: a prospective cohort study. [PDF]

Front Surg
Sguinzi R, Lagger M, Chevalley T, Gremaud B, Menth M, Buhler L, Adamina M.   +6 more
europepmc   +1 more source

Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study [PDF]

Shiyong Zhang, Danni Wang, Jinyu Zhao, Haitong Zhao, Peng Xie, Linli Zheng, Puyi Sheng, Jinqiu Yuan, Bin Xia, Fuxin Wei, Ziji Zhang   +10 more
openalex   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

Assessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study. [PDF]

Cancer Epidemiol Biomarkers Prev
DeMoulin D, Cai H, Cai Q, Zheng W, Shu XO.   +4 more
europepmc   +1 more source