Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
Prospective memory: an alternate explanation for choice of residency. [PDF]
Sawatzky B, Li M, Leung F.
europepmc +1 more source
ABSTRACT European agriculture is increasingly exposed to economic instability driven by extreme weather events, market volatility, and geopolitical tensions. To manage these growing risks, farmers are encouraged to adopt innovative risk management strategies such as the Income Stabilization Tool (IST), which offers protection against severe income ...
Alice Stiletto +5 more
wiley +1 more source
Is Prospective Memory Monitoring Governed by Dual Processes of Initiating a Retrieval Mode and Checking for Targets? A Conceptual Replication and Extension of Guynn (2003). [PDF]
Valdez MR, Bugg JM.
europepmc +1 more source
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita +4 more
wiley +1 more source
AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley +1 more source
Effects of Introducing the Bbrainklok as a Digital External Memory Aid on Prospective Memory, Apathy and Autonomy in Individuals with Korsakoff's Syndrome. [PDF]
Smits S +4 more
europepmc +1 more source
A Language‐Guided Multimodal Foundation Model for Zero‐Shot and Multi‐Task Brain Signal Analysis
METIS aligns brain signals with natural‐language instructions to enable zero‐shot and multi‐task brain signal analysis. Pretrained on over 70 000 h of EEG and iEEG recordings, it generalizes across sleep stage classification, epilepsy detection, and neurological disorder diagnosis, providing a scalable foundation model for clinically meaningful brain ...
Mingzhi Chen +3 more
wiley +1 more source
Sensor-Based Assessment of Morning Prospective Memory in Narcolepsy Type 1: Evidence from Children and Adult Cohorts. [PDF]
Tonetti L +6 more
europepmc +1 more source

