Results 111 to 120 of about 3,392,544 (337)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial [PDF]

, 2010
Christiane Kühl, Stefanie Weigel, Simone Schrading, Birke Arand, Heribert Bieling, Roy König, Bernd Tombach, C Leutner, Andrea Rieber-Brambs, D Nordhoff, Walter Heindel, Maximilian Reiser, Hans H. Schild   +12 more
openalex   +1 more source

Study Of Oxidation Processes In Duck Meat With Application Of Rosemary And Grape Seed Extracts [PDF]

, 2017
The substantiation of the expedience of using antioxidants of a natural origin to decelerate oxidation processes in different meat products is an urgent direction of these studies.
Bozhko, N. (Nataliia), Marynin, A. (Andriy), Pasichnyi, V. (Vasil), Polumbryk, M. (Maksym), Tischenko, V. (Vasyl)   +4 more
core   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Employing social accounting matrix multipliers to profile the bioeconomy in the EU member states: is there a structural pattern?

Spanish Journal of Agricultural Research, 2014
The concept of 'bioeconomy' is gathering momentum in European Union (EU) policy circles as a sustainable model of growth to reconcile continued wealth generation and employment with bio-based sustainable resource usage.
George Philippidis, Ana I. Sanjuán, Emanuele Ferrari, Robert M'barek   +3 more
doaj   +1 more source

The European prospective osteoporosis study

Osteoporosis International, 1996
The objectives of the European Prospective Osteoporosis Study (EPOS) are to identify the causes of the current epidemic of hip and spine fractures affecting Europe and most other continents, with the possible exception of sub-Saharan Africa [1]. They cause much suffering and cost each family in the EU about 60 Ecu/ year.
openaire   +2 more sources

Neurosensory disturbances following bone harvesting in the symphysis: a prospective clinical study [PDF]

, 2005
Thomas von Arx, Jörg Häfliger, Vivianne Chappuis   +2 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Looking Back at Prospective Studies [PDF]

Academic Radiology, 2008
Gur's perspective article raises important points about analytic methods and the clinical inferences drawn from retrospective statistical analyses of prospective studies. Specifically, he associates three problems with the scientific methods of retrospective analyses: (1) using the parametric receiver-operating characteristic (ROC) curve and the area ...
openaire   +2 more sources