Results 101 to 110 of about 15,191,982 (262)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis [PDF]

, 2008
ObjectiveWe investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk.MethodsWe examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women’s Heart and
Lowe, Gordon, Heikkila, K, Gallacher, John, Ebrahim, S, Lowe, G., Gallacher, J., Lawlor, Debbie A, Harris, Ross J, Rumley, A., Yarnell, J, Ebrahim, S., Ben-Shlomo, Y, Ebrahim, Shah, Gallacher, J, Ebrahim, Shah B J, Lowe, GD, Heikkilä, Katriina, Heikkila, K., Harris, R, Harris, Ross, Lawlor, D, Rumley, Ann, Heikkila, H K W, Harris, R., Ben-Shlomo, Y., Ben Shlomo, Y, Lawlor, DA, Rumley, A, Ben-Shlomo, Yoav, Lowe, G, Yarnell, John, Lawlor, D.A.   +31 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Observed/reported ADRs from RCTs and prospective cohort studies.

, 2017
Observed/reported ADRs from RCTs and prospective cohort studies.
Sharon Conroy (3710050), Imti Choonara (642618), Fahad Aljebab (3710047)   +2 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Risk behaviours and non-atopic comorbidities of adolescents with asthmaKey message

World Allergy Organization Journal
Background: Risk behaviours, obesity, and neuropsychiatric comorbidity have been demonstrated in various chronic diseases but are less well described among adolescents with asthma.
Trine Mølbæk-Engbjerg, MD, Nilo Vahman, MD, Ph.D., Mina Ali, MSc, Ph.D., Frederikke Skov, MD, Rebecca Vinding, MD, Ph.D., David Horner, MD, Ph.D., Nicklas Brustad, MD, Ph.D., Jonathan Thorsen, MD, Ph.D., Ann-Marie M. Schoos, MD, Ph.D., DMSc, Jakob Stokholm, MD, Ph.D., Klaus Bønnelykke, MD, Ph.D., Bo Chawes, MD, Ph.D., DMSc   +11 more
doaj   +1 more source

Study characteristics of the included prospective cohort studies.

, 2019
Study characteristics of the included prospective cohort studies.
Karen Roche (6714449), Joy C. MacDermid (4279753), Maya Senthilkumaran (6714446), Kim Sopko (6714452), Goris Nazari (4874380)   +4 more
core   +1 more source