Results 201 to 210 of about 15,191,982 (262)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Mean platelet volume and cardiovascular outcomes in patients with coronary heart disease: A meta-analysis of prospective studies. [PDF]

Medicine (Baltimore)
Wang QC, Chen Y, Guan CL, Lu WK.
europepmc   +1 more source

Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling ...
Jae‐Won Hyun, Shaun G. Hong, Na Young Park, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

Patient- and Clinician-Reported Outcomes and Outcome Measures Evaluating Timing of Implant Loading in the Edentulous Maxilla: A Systematic Review of Prospective Studies. [PDF]

Clin Oral Implants Res
Pannuti CM, Hassan MA, Reis INR, Villar CC, Francisco H, Romito GA.   +5 more
europepmc   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Limited clinical value of exhaled volatile organic compound measurements in childhood asthma

ERJ Open Research, 2018
Maria G. Fuglsbjerg, Morten A. Rasmussen, Kirsten S. Hansen, Agnieszka Smolinska, Jan W. Dallinga, Frederik-Jan van Schooten, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L. Chawes   +9 more
doaj   +1 more source

Endogenous sex steroid hormones, sex hormone binding globulin and risk of all-cause and cardiovascular mortality in patients with established cardiovascular diseases: a systematic review and meta-analysis of prospective studies. [PDF]

Front Endocrinol (Lausanne)
Amiri M, Raeisi-Dehkordi H, Beigrezaei S, Chatelan A, Franco OH, Voortman T, Muka T.   +6 more
europepmc   +1 more source

Anti‐CD20 Discontinuation Versus Continuation in People Aged Over 50 With Non‐Active Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Alexia Moukhine, Fabien Rollot, Romain Casey, Nicolas Collongues, Sandra Vukusic, Guillaume Mathey, Anne Laure Dubessy, Jonathan Ciron, Jérôme De Seze, Aurélie Ruet, Pierre Labauge, Arnaud Kwiatkowski, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun‐Frenay, David Axel Laplaud, Eric Berger, Eric Thouvenot, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Abir Wahab, Laurent Magy, Jean‐Philippe Camdessanché, Ines Doghri, Solène Moulin, Mariana Sarov Rivière, Karolina Hankiewicz, Amélie Dos Santos, Corinne Pottier, Eric Manchon, Jennifer Aboab, Maia Tchikviladze, Thomas David, Gilles Edan, Emmanuelle Le Page, Laure Michel, Anne Kerbrat, OFSEP Investigators   +40 more
wiley   +1 more source

Symptom burden to characterise, predict, and prevent asthma attacks: a patient-level meta-analysis of randomised trials and translational prospective studies.

Lancet Respir Med
Couillard S, Meulmeester FL, Charland P, Lemaire-Paquette S, Howell I, Celis-Preciado C, Lachapelle P, Heaney LG, Bradding P, Mailhot-Larouche S, Ramakrishnan S, Wechsler ME, Brusselle G, Diver SE, Brightling CE, Castro M, Hanania NA, Jackson DJ, Martin N, Moore A, Howarth P, Hardin ME, Gall R, Holweg CTJ, Dharman V, Beasley RW, Sont JK, Steyerberg EW, Pavord ID, Oxford Asthma Attack Risk Scale Meta-analysis (ORACLE2) Consortium.   +29 more
europepmc   +1 more source