Results 61 to 70 of about 15,191,982 (262)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Screen Time Is Associated With Cardiometabolic and Cardiovascular Disease Risk in Childhood and Adolescence

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Screen time in children and adolescents may be linked to cardiometabolic and cardiovascular risk. Methods We analyzed data from >1000 participants in the COPSAC2010 and COPSAC2000 (Copenhagen Prospective Studies on Asthma in Childhood) mother ...
David Horner, Marie Jahn, Klaus Bønnelykke, Bo Chawes, Trine Flensborg‐Madsen, Ann‐Marie Malby Schoos, Jakob Stokholm, Morten Arendt Rasmussen   +7 more
doaj   +1 more source

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort

EBioMedicine, 2022
Summary: Background: Perfluoroalkyl substances PFOS and PFOA are persistent and bioaccumulative exogenous chemicals in the human body with a range of suspected negative health effects. It is hypothesised that exposure during prenatal and early postnatal
Astrid Sevelsted, Gözde Gürdeniz, Daniela Rago, Casper-Emil Tingskov Pedersen, Jessica A. Lasky-Su, Antonio Checa, Pei Zhang, Craig E. Wheelock, Stine S. Normann, David M. Kristensen, Morten Arendt Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo Chawes   +17 more
doaj   +1 more source

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review [PDF]

, 2008
Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Kaptoge Stephen, Kaptoge, S., Lennon, L., Danesh, J, Lucy Lennon, Gudnason, Vilmundur, Stephen Kaptoge, Higgins Julian P. T, Wensley, F, Mann, Andrea G, Rumley, A., Sarwar, N, Wood, A, Ann Rumley, Vilmundur Gudnason, Danesh, J., Angleman, Sara B, Wood, A., Gudnason, V., Danesh John, Kaptoge, S, Wensley Frances, Wood, Angela, Lowe, G.D., John Danesh, Eiriksdottir, Gudny, Rumley, Ann, Angleman Sara B, Wensley, Frances, Gudnason Vilmundur, Sara B Angleman, Whincup Peter H, Kaptoge, Stephen, Gordon D O Lowe, Lennon Lucy, Sarwar, Nadeem, Higgins, JPT, Lennon, L, Higgins, J.P.T., Andrea G Mann, Peter H Whincup, Mann, AG, Lowe, GDO, Whincup, PH, Mann Andrea G, Whincup, P.H., Julian P T Higgins, Higgins, Julian PT, Lowe, Gordon DO, Angleman, S.B., Wensley, F., Sarwar, N., Mann, A.G., Eiriksdottir, G, Higgins, JP, Danesh, John, Sarwar Nadeem, Gudnason, V, Angleman, SB, Eiriksdottir, G., Lowe Gordon D. O, Angela Wood, Frances Wensley, Lowe, GD, Whincup, Peter H, Nadeem Sarwar, Eiriksdottir Gudny, Gudny Eiriksdottir, Wood Angela, Lennon, Lucy, Rumley Ann, Rumley, A   +71 more
core   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Air pollution-induced proteomic alterations increase the risk of child respiratory infections

Nature Communications
Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and ...
Nicklas Brustad, Tingting Wang, Shizhen He, Casper-Emil Tingskov Pedersen, Olena Gruzieva, Liang Chen, Göran Pershagen, Mina Ali, Julie Nyholm Kyvsgaard, Marie Pedersen, Matthias Ketzel, Heikki Hyöty, Daniel Agardh, Erik Melén, Jonathan Thorsen, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes   +17 more
doaj   +1 more source

Diminished time-based, but undiminished event-based, prospective memory among intellectually high-functioning adults with autism: Relation to working memory ability. [PDF]

, 2013
Objective: Prospective memory (PM) is the ability to remember to carry out an intended action. Working memory is the ability to store information in mind while processing potentially distracting information.
Lind, Sophie E, Lind, Sophie E., Grainger, C., Lind, S. E., Williams, David M., Grainger, Catherine, Lind, Sophie, Williams, David, Jarrold, Christopher, Jarrold, C., Williams, D. M., Williams, David M   +11 more
core   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

L'oblit: El dret a ser diferent… d'un mateix. Una reconsideració del dret a ser oblidat

IDP, 2012
Aquest article proposa una nova conceptualització del dret a ser oblidat, argumenta a favor de la seva construcció teòrica i aplicació concreta emparades en el dret a la identitat.
Norberto Nuno Gomes de Andrade
doaj   +1 more source