Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review
Phytotherapy Research, EarlyView.Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley +1 more source
Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2 [PDF]
, 2003 Makoto Murakami +8 more
openalex +1 more source
Iguratimod alleviated Sjögren's syndrome through regulating macrophage polarization
Rheumatology &Autoimmunity, EarlyView.Nonobese diabetic (NOD) mice exhibited characteristic of Sjögren's syndrome (SS), with increased M1 macrophages and deceased M2 macrophages. Iguratimod alleviated SS‐like symptoms and restored balance of macrophage polarization through inhibiting the mitogen‐activated protein kinases pathway in NOD mice.
Junqiao Guo +7 more
wiley +1 more source
IL‐1β‐dependent activation of NF‐κB mediates PGE2 release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase [PDF]
, 2003 Matthew C. Catley +9 more
openalex +1 more source
Micro‐ and nanomotors in biomedical applications
Responsive Materials, EarlyView.Micro‐ and nanomotors (MNMs), as autonomous devices converting chemical or external energy into mechanical propulsion, have emerged as transformative drug delivery platforms in biomedicine. This review systematically outlines the design principles governing MNMs' propulsion and operation, highlights the applications of MNMs in disease treatment, and ...
Xiangyu Meng, Yuqi Tang, Quan Li
wiley +1 more source
Expression of microsomal prostaglandin E synthase‐1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines [PDF]
, 2003 Bastiaan P. van Rees +6 more
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Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
United European Gastroenterology Journal, EarlyView.ABSTRACT Intestinal stricture remains one of the most challenging complications in Crohn's disease, and its underlying mechanisms are poorly understood. Accumulating evidence suggests that gut microbiota is significantly altered in stenotic intestines and may play a key role in the development of fibrogenesis in Crohn's disease.
Caiguang Liu +14 more
wiley +1 more source
FASEB BioAdvances, EarlyView.Plasmalogens are specialized lipids affecting the membrane structure, dynamics, and key cell signaling pathways. They protect cells from oxidative damage. Plasmalogen deficiency is associated with severe diseases. Lipid nanoparticles and nanomedicine offer unexplored therapeutic potential for restoring plasmalogen levels under pathological conditions ...
Yu Wu +3 more
wiley +1 more source
Induction of prostaglandin E synthase and cyclooxygenase-2 in the LPS-treated niurine macrophages
, 2000 Fumiaki Kojinia +3 more
openalex +1 more source
Allergy, EarlyView.We profiled PBMCs in severe asthma patients at baseline and after initiating treatment with mepolizumab or dupilumab. Mepolizumab treatment increases ILC2, Th2, and Tc2 cell frequencies, skewing ILC2 towards CD117low and Th2/Tc2 cells towards a central memory phenotype.
Lorenz Wirth +22 more
wiley +1 more source