Results 131 to 140 of about 6,685 (245)

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Expression of Prostaglandin I₂Synthase, but Not Prostaglandin E Synthase, Changes in Myometrium of Women at Term Pregnancy [PDF]

, 2002
D. Giannoulias, Nadia Alfaidy, Alison C. Holloway, William Gibb, Mingjun Sun, S. J. Lye, J. R. G. Challis   +6 more
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Allosteric regulation of prostaglandin endoperoxide H₂ synthases. [PDF]

J Biol Chem
Dong L, Malkowski MG.
europepmc   +1 more source

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng, Yunlong Xia, Huishou Zhao, Yongzhen Guo, Xiaoming Xu, Xue Han, Shiyue Wang, Fengyue Ding, Quanchi Liu, Congye Li, Yuan He, Zhaoyi Luo, Qiaojuan Wang, Xing Zhang, Feng Gao, Yajing Wang, Yulin Li, Shengpeng Wang, Ling Tao, Wenjun Yan   +19 more
wiley   +1 more source

Functional characterization of eicosanoid signaling in Drosophila development. [PDF]

PLoS Genet
Fujinaga D, Nolan C, Yamanaka N.
europepmc   +1 more source

Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2

, 2003
Makoto Murakami, Karin Nakashima, Daisuke Kamei, Seiko Masuda, Yukio Ishikawa, Toshiharu Ishii, Yoshihiro Ohmiya, Kikuko Watanabe, Ichiro Kudo   +8 more
openalex   +1 more source

Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development [PDF]

, 2006
Tong Sun, Wenbo Deng, Honglu Diao, Hua Ni, Yuyan Bai, Xinghong Ma, Libin Xu, Zeng‐Ming Yang   +7 more
openalex   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

In vitro expression of genes encoding HIF1α, VEGFA, PGE2 synthases, and PGE2 receptors in feline oral squamous cell carcinoma. [PDF]

J Vet Diagn Invest
Nasry WHS, Rodriguez-Lecompte JC, Martin CK.   +2 more
europepmc   +1 more source