Results 1 to 10 of about 143,550 (306)

Imbalance of endogenous prostanoids in moderate-to-severe asthma

Allergology International, 2017
Background: Inhalation studies suggested “protective” roles of exogenous prostaglandin E2, but the clinical relevance of endogenous prostanoids in asthma is poorly known. The objective of this study is to measure sputum levels of prostanoids in asthmatic
Masaya Takemura, Akio Niimi, Hisako Matsumoto, Tetsuya Ueda, Masafumi Yamaguchi, Hirofumi Matsuoka, Makiko Jinnai, Kian Fan Chung, Michiaki Mishima   +8 more
doaj   +2 more sources

Prostaglandin E2, an Immunoactivator

Journal of Pharmacological Sciences, 2010
Diseases caused by immune inflammation, such as rheumatoid arthritis, multiple sclerosis, and Crohn’s disease, are intractable diseases to which novel therapeutics are highly demanded.
Daiji Sakata, Chengcan Yao, Shuh Narumiya   +2 more
doaj   +4 more sources

Rotavirus-Mediated Prostaglandin E2 Production in MA104 Cells Promotes Virus Attachment and Internalisation, Resulting in an Increased Viral Load

Frontiers in Physiology, 2022
Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known anti-viral treatments ...
Willem J. Sander, Gabré Kemp, Arnold Hugo, Carolina H. Pohl, Hester G. O’Neill   +4 more
doaj   +1 more source

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul, Balschun, Tobias, Brand, Stephan, Czamara, Darina, Diegelmann, Julia, Duerr, Richard H., Franke, Andre, Glas, Jürgen, Kamboh, M. Ilyas, Müller-Myhsok, Bertram, Olszak, Torsten, Pasciuto, Giulia, Seiderer, Julia, Wetzke, Martin, Wolf, Christiane   +14 more
core   +11 more sources

Dynamics of prostaglandin E2 in the surgical treatment of gastroesophageal reflux disease

Patologìâ, 2023
Gastroesophageal reflux disease (GERD) is one of the most common gastroenterological diseases. Therefore, the issues of diagnosis and the most effective treatment of GERD are extremely relevant.
Ye. I. Haidarzhi
doaj   +1 more source

Prostaglandin E2 synthases.

Folia Pharmacologica Japonica, 2002
Prostaglandin E2 (PGE2) is widely distributed in various tissues, and exhibits various biologically important activities. PGE2 synthase (PGES) catalyzes conversion of COX-derived PGH2 to PGE2. It now appears that there are at least three distinct types of PGES in mammals. We identified two distinct glutathione-dependent PGESs.
Yoshihito, Nakatani, Ichiro, Kudo
openaire   +5 more sources

Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer’s model

Life Science Alliance, 2022
PGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.
Charles H Wallace, Giovanni Oliveros, Peter A Serrano, Patricia Rockwell, Lei Xie, Maria Figueiredo-Pereira   +5 more
doaj   +1 more source

Is there a difference in labor patterns after induction with prostaglandins and double-balloon catheters?AJOG Global Reports at a Glance

AJOG Global Reports, 2023
BACKGROUND: Labor progression curves are believed to differ between spontaneous and induced labors. However, data describing labor progression patterns with different modes of induction are insufficient.
Hila Shalev-Ram, MD, Roi Cirkin, MD, Gal Cohen, MD, Shai Ram, MD, Yoram Louzoun, MD, Michal Kovo, MD, Tal Biron-Shental, MD   +6 more
doaj   +1 more source

Relationships between prostaglandin concentrations, a single nucleotide polymorphism in HSD17B12, and reproductive performance in dairy cows

Journal of Dairy Science, 2022
: Prostaglandins are involved in multiple processes important for fertility, with previous work in mice highlighting a potential role for the HSD17B12 gene in prostaglandin biosynthesis.
J.L. Juengel, E.M.O. Mosaad, M.D. Mitchell, C.V.C. Phyn, M.C. French, E.D. Meenken, C.R. Burke, S. Meier   +7 more
doaj   +1 more source

Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E in rat microglial cultures [PDF]

, 2005
Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
R. De Simone, M. A. Ajmone Cat, L. Minghetti, CARNEVALE, DANIELA   +3 more
core   +1 more source