Results 41 to 50 of about 214,655 (309)
Interplay between the prostaglandin transporter OATP2A1 and prostaglandin E2-mediated cellular effects. [PDF]
, 2015 Prostaglandins such as prostaglandin E2 (PGE2) play a pivotal role in physiological and pathophysiological pathways in gastric mucosa. Little is known about the interrelation of the prostaglandin E (EP) receptors with the prostaglandin transporter ...
Schmidt, Ingrid +6 more
core +1 more source
Journal of Pharmacological Sciences, 2006 Prostaglandin E2-receptor subtypes, EP1, EP2, EP3, and EP4, are present in the kidney. The aim of this study was to elucidate the anti-nephritic effect of an EP4-receptor agonist on an experimental nephritic model. Mice were injected i.v.
Tadashi Nagamatsu +6 more
doaj +1 more source
mRNA expression and antilipolytic role of phosphodiesterase 4 in rat adipocytes in vitro
Journal of Lipid Research, 2007 Adipocyte lipolysis is dependent on an increase in the intracellular concentration of cAMP. Intracellular phosphodiesterases (PDEs) hydrolyze cAMP and limit stimulation of lipolysis.
Wang Hong, Neilé K. Edens
doaj +1 more source
추간판내 Prostaglandin E2 양의 임상적 의의 [PDF]
, 2000 Objective: A prospective biochemical assay of prostaglandin E2 content in symptomatic lumbar disc materials was done in order to clarify the pathogenesis of lumbar radiculopathy.
조, 기홍 +6 more
core +1 more source
Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E Synthesis in Endothelial Cells [PDF]
International Neurourology Journal, 2016 Purpose Rocuronium bromide is a nondepolarizing neuromuscular blocking drug and has been used as an adjunct for relaxation or paralysis of the skeletal muscles, facilitation of endotracheal intubation, and improving surgical conditions during general ...
Sang Bin Baek +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Effects of Changes in Sodium Balance on Prostaglandin Synthesis and Prostaglandin E2 9-Ketoreductase Activity in the Rat Kidney [PDF]
, 1989 Summary: The in vitro synthesis of prostaglandins E2 and F2a by renal cortex, medulla and papilla was measured in normal rats and in rats receiving either a low or a high sodium intake for 14 days.
Podjarny, E. +9 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction [PDF]
, 2020 Among prostaglandins, Prostaglandin E2 (PGE2) (PGE2) is considered especially important for decidualization, ovulation, implantation and pregnancy.
Junyan Zhu +9 more
core +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source