Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production [PDF]
, 2004 Levels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2).
McAnulty, R J +35 more
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Hemodynamic Effects of Prostaglandin E2 [PDF]
Obstetric Anesthesia Digest, 1989 Prostaglandin (PG)E 2 has been used in obstetrics for several years as a mid-trimester abortifacient. The known side effects of PGE 2 include an increase in heart rate, pyrexia in 40% of patients, and tachypnea, which are well known to obstetricians.
W A, Hughes, S C, Hughes
openaire +2 more sources
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Geisslinger, Gerd +17 more
core +1 more source
Improved homology modeling of the human & rat EP4 prostanoid receptors
BMC Molecular and Cell Biology, 2019 Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote development of ...
Melissa C. Holt +4 more
doaj +1 more source
Iraqi Journal of Pharmaceutical Sciences, 2017 Many reports confirm ulcers as an adverse effect of drugs such as nicorandil and aspirin. The exact responsible mechanisms of ulceration have until now not proved.
Asma A. Hayder, Tagreed S. Altaei
doaj +3 more sources
Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]
, 2007 Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration ...
Williams, A R +5 more
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Mediators of Inflammation, 1998 Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo +5 more
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Imbalance of endogenous prostanoids in moderate-to-severe asthma
Allergology International, 2017 Background: Inhalation studies suggested “protective” roles of exogenous prostaglandin E2, but the clinical relevance of endogenous prostanoids in asthma is poorly known. The objective of this study is to measure sputum levels of prostanoids in asthmatic
Masaya Takemura +8 more
doaj +1 more source
Prostaglandin E2 in apical tissue fluid and postoperative pain in intact and teeth with large restorations in two endodontic treatment visits [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2013 Introduction. Acute periapical inflammation is the most common cause of postoperative pain developing as a result of mechanical, chemical and/or microbial injury of periapical tissue.
Grga Đurica +3 more
doaj +1 more source
Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo
Journal of Lipid Research, 1998 D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid.
Jason D. Morrow +4 more
doaj +1 more source