Results 171 to 180 of about 4,678 (214)
Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating. [PDF]
Am J Physiol Regul Integr Comp PhysiolTurner CG +5 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Prostaglandin endoperoxide synthase: structure and catalysis
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991In this review, we describe the properties of PGH synthase, the enzyme which catalyzes the committed step in the synthesis of prostaglandins and thromboxane. We begin by presenting an overview of protanoid biosynthesis and the mechanism of action of these local hormones. We then describe the novel characteristics of the two distinct reactions catalyzed
W L, Smith, L J, Marnett
openaire +2 more sources
Prostaglandin endoperoxide synthases-1 and -2
Journal of Lipid Mediators and Cell Signalling, 1995Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs).
J C, Otto, W L, Smith
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1994
A Prostaglandin endoperoxide synthase isoenzyme was recently identified in several cell lines. Osteoblasts possess Prostaglandin endoperoxide synthase activity, but it is not known which isoenzymes are present in these cells. Our objective was to identify these isoenzymes in human osteoblasts. Resting cells in culture did not produce measurable amounts
A J, de Brum-Fernandes +7 more
openaire +2 more sources
A Prostaglandin endoperoxide synthase isoenzyme was recently identified in several cell lines. Osteoblasts possess Prostaglandin endoperoxide synthase activity, but it is not known which isoenzymes are present in these cells. Our objective was to identify these isoenzymes in human osteoblasts. Resting cells in culture did not produce measurable amounts
A J, de Brum-Fernandes +7 more
openaire +2 more sources
Prostaglandin endoperoxide synthase: why two isoforms?
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1996Prostaglandin endoperoxide synthase-1 [prostaglandin G/H synthase-1 (PGHS-1)] and PGHS-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. We refer to these isoforms as cyclooxygenase-1 (COX-1) and COX-2 in this review.
C S, Williams, R N, DuBois
openaire +2 more sources
Expression of prostaglandin endoperoxide synthase in rat brain
Molecular Brain Research, 1993Developmental and regional expression of prostaglandin endoperoxide synthase (PES) transcript was examined in the rat brain and in primary mixed cultures of neurons and glial cells from neonatal brain. Although the PES mRNA level in the brain was much lower than that in peripheral rat tissues such as lung, liver, spleen and kidney, a significant 3.0 kb
M, Kawasaki +3 more
openaire +2 more sources
Prostaglandin endoperoxide synthase isozymes
1997Abstract PGH synthases catalyze the initial reaction common to the formation of prostanoids and are the target sites for most nonsteroidal anti-inflammatory drugs (NSAIDs). Until the recent discovery of a second PGH synthase isozyme (PGH synthase-2; PGHS-2), it was thought that NSAIDs acted by inhibiting a single enzyme, now referred to as PGH ...
William L. Smith, David L. DeWitt
openaire +1 more source
Prostaglandin Endoperoxide H Synthases-1 and -2
1996Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs). There are three general areas of study important to understanding more about
W L, Smith, D L, Dewitt
openaire +2 more sources
Mechanism of Hydroperoxide Reduction by Mangano-Prostaglandin Endoperoxide Synthase
Biochemistry, 1996Reaction of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hydroperoxyeicosatetraenoic acid (15-HPETE) generates two products in nearly equal amounts: 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-ketoeicosatetraenoic acid (15-KETE) [Kulmacz et al. (1994) Biochemistry 33, 5428-5439]. Their proposed mechanism to explain
L M, Landino, L J, Marnett
openaire +2 more sources