The persistent homology of mitochondrial ATP synthases [PDF]
iScience, 2023 Summary: Relatively little is known about ATP synthase structure in protists, and the investigated ones exhibit divergent structures distinct from yeast or animals.
Savar D. Sinha, Jeremy G. Wideman
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Defueling the cancer: ATP synthase as an emerging target in cancer therapy
Molecular Therapy: Oncolytics, 2021 Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase (MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing proteins is found during cancer and is linked to a poor prognosis in ...
Ting Wang, Fei Ma, Hai-li Qian
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Investigating the relationship between ATP synthase and the TCA cycle by crosslinking mass spectrometry [PDF]
Nature CommunicationsMitochondrial oxidative phosphorylation (OXPHOS) comprises multi-subunit protein complexes that operate in coordination with the tricarboxylic acid (TCA) cycle to generate ATP.
Laura Pérez Pañeda +4 more
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Reversal of ATP synthase is a key attribute accompanying cellular differentiation of Trypanosoma brucei insect forms [PDF]
Communications BiologyThe mitochondrial FoF1-ATP synthase is a reversible nanomachine that normally produces ATP via oxidative phosphorylation but under stress conditions it can reverse to maintain the mitochondrial membrane potential at the expense of ATP, a process ...
Michaela Kunzová +4 more
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ATP Synthase Abundance in Neuronal Extracellular Vesicles Reflects Changes in the Mitochondria of Parent Neurons [PDF]
Journal of Extracellular VesiclesMitochondrial proteins are found in extracellular vesicles (EVs) such as neuron‐derived EVs (NEVs). Yet whether and how NEV‐borne mitochondrial proteins relate to the state of mitochondria in the parent neurons is unclear.
Pamela J. Yao +3 more
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Subtomogram averages of mitochondrial ATP synthase dimers from plants show a conserved extra density at the peripheral stalk [PDF]
IUCrJWe analyzed ATP synthase dimers in mitochondria purified from four plant species by subtomogram averaging, using Saccharomyces cerevisiae as a control.
Thorsten B. Blum +2 more
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Structure of a bacterial ATP synthase [PDF]
eLife, 2018 Abstract ATP synthases produce ATP from ADP and inorganic phosphate with energy from a transmembrane proton motive force. Bacterial ATP synthases have been studied extensively because they are the simplest form of the enzyme and because of the relative ease of genetic manipulation of these complexes. We expressed the
Hui Guo +2 more
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ATP Synthase Members of Chloroplasts and Mitochondria in Rubber Trees (Hevea brasiliensis) Response to Plant Hormones [PDF]
PlantsATP synthase is a key enzyme in photophosphorylation in photosynthesis and oxidative phosphorylation in respiration, which can catalyze the synthesis of ATP and supply energy to organisms. ATP synthase has been well studied in many animal species but has
Bingbing Guo +5 more
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Imaging of mitochondrial matrix pH dynamics reveals a functional interaction between the ADP/ATP carrier and ATP synthase to regulate H+ distribution [PDF]
Pharmacological ResearchIn mitochondria, the energy derived from the proton gradient across the mitochondrial inner membrane (IMM) is converted into ATP and heat. For these conversions to occur, H+ is pumped out of the matrix via the electron transport chain (ETC) and then re ...
Bernard Ribalet +4 more
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ATP Synthase: Structure, Function and Inhibition
Biomolecular Concepts, 2019 Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through ...
Neupane Prashant +3 more
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