Advances in protein subunit vaccines against tuberculosis [PDF]
Frontiers in Immunology, 2023 Tuberculosis (TB), also known as the “White Plague”, is caused by Mycobacterium tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any single infectious disease.
Ying Zhang +5 more
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Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. [PDF]
PLoS ONE, 2012 Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before ...
Sandra M McLachlan +4 more
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A Comprehensive Review of the Protein Subunit Vaccines Against COVID-19 [PDF]
Frontiers in Microbiology, 2022 Two years after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in December 2019, the first infections were identified in Wuhan city of China.
Mohsen Heidary +7 more
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Advances in protein subunit vaccines against H1N1/09 influenza [PDF]
Frontiers in ImmunologyThe A/H1N1pdm09 influenza virus, which caused the 2009 pandemic, has since become a recurring strain in seasonal influenza outbreaks. Given the ongoing threat of influenza, protein subunit vaccines have garnered significant attention for their safety and
Yu Zhang +9 more
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An RNA-Scaffold Protein Subunit Vaccine for Nasal Immunization [PDF]
Vaccines, 2023 Developing recombinant proteins as nasal vaccines for inducing systemic and mucosal immunity against respiratory viruses is promising. However, additional adjuvants are required to overcome the low immunogenicity of protein antigens.
Joy-Yan Lam +6 more
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Evaluating passive immunity in piglets from sows vaccinated with a PEDV S protein subunit vaccine [PDF]
Frontiers in Cellular and Infection MicrobiologyPorcine epidemic diarrhea virus (PEDV) is a highly contagious virus that causes severe diarrhea and high mortality in neonatal piglets. Current control measures, such as inactivated and live-attenuated vaccines, have limitations in providing complete ...
Jiajia Liu +13 more
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Case report: Myocarditis following COVID-19 protein subunit vaccination [PDF]
Frontiers in Cardiovascular Medicine, 2022 We report findings in a 34-year-old female patient who presented with fulminant myocarditis 8 days after receiving the first dose of the ZF2001 RBD-subunit vaccine against coronavirus disease 2019 (COVID-19).
Yi-ming Dong +11 more
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ECMpy, a Simplified Workflow for Constructing Enzymatic Constrained Metabolic Network Model
Biomolecules, 2022 Genome-scale metabolic models (GEMs) have been widely used for the phenotypic prediction of microorganisms. However, the lack of other constraints in the stoichiometric model often leads to a large metabolic solution space being inaccessible. Inspired by
Zhitao Mao +6 more
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An Overview of SARS-CoV-2 Etiopathogenesis and Recent Developments in COVID-19 Vaccines
Biomolecules, 2023 The Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has significantly impacted the health and socioeconomic status of humans worldwide.
Dona Susan Mathew +4 more
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mBio, 2023 The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for safe and effective vaccines to be rapidly developed and distributed worldwide, especially considering the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
Muhammad S. Khan +14 more
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