Results 31 to 40 of about 191,822 (304)

Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium

Frontiers in Plant Science, 2015
The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts.
Abir U Igamberdiev, Leszek A Kleczkowski
doaj   +1 more source

Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. [PDF]

PLoS ONE, 2017
Reduced cellular ATP synthesis due to impaired mitochondrial function of immune cells may be a factor influencing the immune response in septic shock. We investigate changes in mitochondrial function and bioenergetics of human monocytes and lymphocyte ...
Tobias M Merz, Adriano J Pereira, Roger Schürch, Joerg C Schefold, Stephan M Jakob, Jukka Takala, Siamak Djafarzadeh   +6 more
doaj   +1 more source

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Microbiology Spectrum, 2023
The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discovered the novel
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber   +15 more
doaj   +1 more source

Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth. [PDF]

PLoS ONE, 2015
We examined the thymoquinone induced inhibition of purified F1 or membrane bound F1FO E. coli ATP synthase. Both purified F1 and membrane bound F1FO were completely inhibited by thymoquinone with no residual ATPase activity. The process of inhibition was
Zulfiqar Ahmad, Thomas F Laughlin, Ismail O Kady   +2 more
doaj   +1 more source

ATP binding by an F1Fo ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria

Frontiers in Molecular Biosciences, 2023
It is a conjecture that the ε subunit regulates ATP hydrolytic function of the F1Fo ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended conformation, with a terminal helix probing into the central architecture of the ...
Alexander Krah, Alexander Krah, Timothy Vogelaar, Sam I. de Jong, Jolyon K. Claridge, Peter J. Bond, Peter J. Bond, Duncan G. G. McMillan, Duncan G. G. McMillan   +8 more
doaj   +1 more source

Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth

Cell Reports, 2022
Summary: Invaginations of the mitochondrial inner membrane, termed cristae, are hubs for oxidative phosphorylation. The mitochondrial contact site and cristae organizing system (MICOS) and the dimeric F1Fo-ATP synthase play important roles in controlling
Heike Rampelt, Florian Wollweber, Mariya Licheva, Rinse de Boer, Inge Perschil, Liesa Steidle, Thomas Becker, Maria Bohnert, Ida van der Klei, Claudine Kraft, Martin van der Laan, Nikolaus Pfanner   +11 more
doaj   +1 more source

Structure, Regulation, and Significance of Cyanobacterial and Chloroplast Adenosine Triphosphate Synthase in the Adaptability of Oxygenic Photosynthetic Organisms

Microorganisms
In cyanobacteria and chloroplasts (in algae and plants), ATP synthase plays a pivotal role as a photosynthetic membrane complex responsible for producing ATP from adenosine diphosphate and inorganic phosphate, utilizing a proton motive force gradient ...
Siyan Yi, Xin Guo, Wenjing Lou, Shaoming Mao, Guodong Luan, Xuefeng Lu   +5 more
doaj   +1 more source

An overview of ATP synthase, inhibitors, and their toxicity

Heliyon, 2023
Mitochondrial complex V (ATP synthase) is a remarkable molecular motor crucial in generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism cannot be overstated, as malfunction of ATP synthase has been linked to various ...
Arwa R. Althaher, Mohammad Alwahsh
doaj   +1 more source

Identification of cryptic subunits from an apicomplexan ATP synthase

eLife, 2018
The mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary portions of the complex.
Diego Huet, Esther Rajendran, Giel G van Dooren, Sebastian Lourido   +3 more
doaj   +1 more source

Assembly of F1F0-ATP synthases

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2015
F1F0-ATP synthases are multimeric protein complexes and common prerequisites for their correct assembly are (i) provision of subunits in appropriate relative amounts, (ii) coordination of membrane insertion and (iii) avoidance of assembly intermediates that uncouple the proton gradient or wastefully hydrolyse ATP.
Rühle, Thilo, Leister, Dario
openaire   +2 more sources