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The ATP Synthase Deficiency in Human Diseases [PDF]
Life, 2021 Human diseases range from gene-associated to gene-non-associated disorders, including age-related diseases, neurodegenerative, neuromuscular, cardiovascular, diabetic diseases, neurocognitive disorders and cancer. Mitochondria participate to the cascades of pathogenic events leading to the onset and progression of these diseases independently of their ...
Galber, Chiara +3 more
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mBio, 2023 Coiled-coil-helix-coiled-coil-helix (CHCH) domains consist of two pairs of cysteine residues that are oxidized to form disulfide bonds upon mitochondrial import.
Madelaine M. Usey, Diego Huet
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Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes
Antioxidants, 2020 Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown.
James Cobley +4 more
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Assembling the mitochondrial ATP synthase [PDF]
Proceedings of the National Academy of Sciences, 2018 Mitochondria are known as the powerhouses of the cell. The F1Fo-ATP synthase of the mitochondrial inner membrane produces the bulk of cellular ATP. The respiratory chain complexes pump protons across the inner membrane into the intermembrane space and thereby generate a proton-motive force that drives the ATP synthase.
Jiyao Song +2 more
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Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 A model is presented in which ion translocation through the F0 part of the ATP synthase drives the rotation of the ring of c subunits (rotor) versus the a subunit (stator). The coupling ion binding sites on the rotor are accessible from the cytoplasm of a bacterial cell except for the c subunit at the interface to the stator.
Dimroth P, Kaim G, Matthey U
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The EMBO Reports, 2000 All living species use ATP as a general source of energy by hydrolysing it into ADP and phosphate. In most species the regeneration of this vital molecule is catalysed by the H+-transporting F1F0 ATP synthases, marvellous machines that couple the flow of protons down an electrochemical gradient to form ATP from ADP and phosphate.
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Molecules, 2023 Polyphenols have attracted attention in the fight against antibiotic-resistant bacteria, as they show antibacterial action. Considering that polyphenols inhibit F1Fo-ATP synthase (ATP synthase) and that bacteria need a constant energy production to ...
Silvia Ravera +4 more
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The rotary mechanism of the ATP synthase [PDF]
Archives of Biochemistry and Biophysics, 2008 The F0F1 ATP synthase is a large complex of at least 22 subunits, more than half of which are in the membranous F0 sector. This nearly ubiquitous transporter is responsible for the majority of ATP synthesis in oxidative and photo-phosphorylation, and its overall structure and mechanism have remained conserved throughout evolution. Most examples utilize
Robert K, Nakamoto +2 more
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Cell Death and Disease, 2023 ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly variable.
Sonia Domínguez-Zorita +9 more
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Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
Frontiers in Molecular Biosciences, 2022 The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites.
Brad Ebanks +2 more
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