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Conversions of prostaglandin endoperoxides by prostacyclin synthase from pig aorta
Prostaglandins, 1980Partially purified prostacyclin synthase from pig aorta converted the prostaglandin (PG) endoperoxide PGH2 to prostacyclin (PGI2), and PGH1 to 12-hydroxy-8,10-heptadecadienoic acid (HHD). Both reactions were inhibited by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HP) in a dose-dependent rashion.
P, Wlodawer, S, Hammarström
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Characterization of prostaglandin endoperoxide synthase from a human cell line
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986Prostaglandin endoperoxide synthase has been purified from the recently established human lung tumor cell line, Lu-65. By gel filtration, the purified enzyme migrated with a relative molecular weight of 115,000, unlike the ovine enzyme, which migrated at 155,000.
N J, Hickok, G, Chin, R S, Bockman
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Inactivation of Prostaglandin Endoperoxide Synthase (PGHS) by N-(Substituted)Maleimides
1997Prostaglandin endoperoxide synthase (PGHS, EC 1.14.99.1) catalyzes the first two steps of prostaglandin biosynthesis.1 Its cyclooxygenase activity oxygenates arachidonic acid to form PGG2; the peroxidase activity of the enzyme then reduces PGG2 in the presence of a reducing substrate to the corresponding alcohol PGH2.2,3 The cyclooxygenase activity is ...
A S, Kalgutkar, B C, Crews, L J, Marnett
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Prostaglandin Endoperoxide Synthases
2010Melissa V. Turman, Lawrence J. Marnett
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Thromboxane synthase inhibition: Implications for prostaglandin endoperoxide metabolism
Prostaglandins, 1986Duncan Haworth, Frank Carey
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