Results 181 to 190 of about 482,690 (387)

Phospholipid precursors of prostaglandins [PDF]

, 1968
William E.M. Lands, Bengt Samuelsson
openalex   +1 more source

Carborane‐based Analogues of Celecoxib and Flurbiprofen, their COX Inhibition Potential and COX Selectivity Index

ChemMedChem, Accepted Article.
The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions as well as its role in cancer and neurodegenerative diseases necessitates the need to develop and improve non‐steroidal anti‐inflammatory drugs.
Lea Ueberham, Jonas Schädlich, Kim Schramke, Sebastian Braun, Christoph Selg, Markus Laube, Peter Lönnecke, Jens Pietzsch, Evamarie Hey-Hawkins   +8 more
wiley   +1 more source

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source

THE OCCURRENCE OF PROSTAGLANDIN E₂ IN SPLENIC VENOUS BLOOD OF THE DOG FOLLOWING SPLENIC NERVE STIMULATION [PDF]

, 1968
B. N. Davies, E. W. HORTON, P.G. Withrington   +2 more
openalex   +1 more source

A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin‐Converting Enzyme Inhibitors

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre, Annette D. Lista, Nick Paulson, Lorianne Masuoka   +3 more
wiley   +1 more source

Followup Results of a Combination of Calcitonin Gene-Related Peptide and Prostaglandin E1 in the Treatment of erectile Dysfunction. [PDF]

, 1993
Aboseif, Abozeid, Benard, Brindley, Gerstenberg, Holmquist, Holmquist, Holmquist, Ignarro, Ishii, Jevtich, Jünemann, Kim, Kirkeby, Mayer, Meuleman, Nelson, Raud, Schwarzer, Stackl, Stief, Stief, Stief, Stief, Stief, Thiebaud, Virag, von Anrep, Waldhauser, Zorgniotti   +29 more
core   +1 more source

The effects of prostaglandins E₁, F_1α and F_2α on monosynaptic reflexes

, 1968
P Duda, E. W. HORTON, Angus McPherson
openalex   +2 more sources

The Isolation of Prostaglandin E from Sheep Prostate Glands. [PDF]

, 1960
Sune Bergström, Jan Sjövall, S. Rundqvist, E. Varde, Gertrud Westin   +4 more
openalex   +1 more source

Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates

Drug Testing and Analysis, EarlyView.
The detection of bisphosphonates is important due to the potential integrity and welfare issues associated with use of these substances. Targeted detection of a nitrogenous and non‐nitrogenous bisphosphonate was detected for 8 h and 28 days post‐administration, respectively.
Kathy Tou, Adam Cawley, Glenys Noble, Jaymie Loy, David Bishop, John Keledjian, Kireesan Sornalingam, Stacey Richards, Shanlin Fu   +8 more
wiley   +1 more source

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Molecular Reproduction and Development, Volume 89, Issue 12, Page 608-631, December 2022., 2022
Abstract Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation.
Katie L. Land, Frances G. Miller, Ava C. Fugate, Patrick R. Hannon   +3 more
wiley   +1 more source