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Prostaglandins

Annual Review of Biochemistry, 1975
AbstractThe prostaglandins are lipid‐soluble C20‐carboxylic acids containing a five‐membered ring, several oxygen function, and at least one double bond. They are found in animal organisms where they stimulate, inter alia, the smooth muscle. In the last decade more has been learned about the occurrence, biosynthesis, metabolism and pharmacological ...
B, Samuelsson   +4 more
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Prostaglandins

Journal of Cardiovascular Pharmacology, 1984
A discussion of important aspects of the effects of prostaglandins on arteries must include (a) the nature of the receptors for the different humoral agents, (b) the potential modulatory role that endogenously produced prostaglandins may play when other vasoactive hormones are present, and (c) the potential for cell-to-cell transfer of substrates for ...
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Specific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1

Journal of the American Chemical Society, 1971
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
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The Prostaglandins

JAMA: The Journal of the American Medical Association, 1975
The introduction of dinoprost tromethamine (Prostin F2 Alpha) as an abortifacient in the second trimester of pregnancy represents the first clinical use of a prostaglandin. Various synthetic analogues of the naturally occurring derivatives are being employed investigationally in the treatment of peptic ulcer, hypertension, asthma, and hypercalcemia. In
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