Results 191 to 200 of about 347,774 (279)

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Predicting mucosal healing in patients with ulcerative colitis in clinical remission using biomarkers: A single-center prospective pilot study. [PDF]

Medicine (Baltimore)
Kato N, Kusunoki R, Kamada H, Semba S, Teraoka Y, Mizumoto T, Tamaru Y, Hatakeyama T, Yamaguchi A, Kouno H, Yoshida S, Kuwai T.   +11 more
europepmc   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Effects of Long-term Weightless Stimulating by Tail Suspension on the Gut Microbiota as well as the Gut-liver Axis Homeostasis in Rat. [PDF]

BMC Microbiol
Chen P, Chen J, Xu N, Wang W, Hou L, Sun B, Lan H, Liu W, Shen Q, Yu Y, Zang P.   +10 more
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Role of the nitric oxide donor linsidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction [PDF]

, 1994
Armin J. Becker, Burnett, Bush, Carrier, Christian G. Stiff, Djamilian, Holmquist, Ignarro, Jünemann, Meyer, Michael C. Truss, Mohamad H. Djamilian, Rajfer, Stief, Stief, Udo Jonas, Wegner, Wetterauer   +17 more
core   +1 more source

Oral misoprostol (PGE1) vs vaginal dinoprostone (PGE2) for labor induction: individual participant data meta‐analysis of randomized controlled trials

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To compare the effectiveness and safety of oral misoprostol vs vaginal dinoprostone for the induction of labor (IOL) using an individual participant data (IPD) meta‐analysis. Methods We used a Cochrane review and searched Ovid MEDLINE, Ovid Embase, Ovid Emcare, CINAHL Plus, Scopus and ClinicalTrials.gov to identify randomized ...
S. Y. Tan, N. Au, M. D. Peel, J. M. Dodd, A. Deussen, P. A. Le Roux, D. C. Young, F. Tessier, P. Dallenbäch, D. M. R. Croll, M. Patabendige, K. Palmer, W. Li, B. W. Mol   +13 more
wiley   +1 more source

Prostaglandin E₂ induces dendritic cell dysfunction in skin involvement of breast cancer. [PDF]

Cell Death Dis
Wang J, Zhong X, Liu X, Qian Z, Zhu J, Lin H, Zhang J, Zhang W, Du S, Yang L, Nie M.   +10 more
europepmc   +1 more source

Anti-Inflammatory Lindolin Alkaloids Repress the Transcription of the Microsomal Prostaglandin E₂ Synthase-1 Gene in Macrophages. [PDF]

J Nat Prod
Jordan PM, Rassbach J, Gräfe M, Peltner LK, Willing K, Zenkel L, Günther K, Sonnabend R, Regestein L, Werz O, Gressler M.   +10 more
europepmc   +1 more source

Intravenous paracetamol does not have significant opioid‐sparing effects when used as part of a multimodal analgesic protocol in dogs undergoing elective orthopaedic surgery

Veterinary Record, EarlyView.
Abstract Background Data evaluating paracetamol combined with NSAIDs in dogs are scarce. Results of clinical studies in dogs investigating intravenous paracetamol vary. Methods Dogs were randomised to either receive 10 mg/kg paracetamol intravenously after induction of anaesthesia and every 8 hours during hospitalisation (test) or not (control).
Robin Stallard, Julia Deutsch, Joanna Murrell   +2 more
wiley   +1 more source