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Neuroscience Research, 1997
Prostaglandin D2 (PGD2) is the endogenous sleep inducing substance in rats, mice, monkeys and probably in humans. PGD synthase (PGDS), the enzyme that produces PGD2 in the brain, is the key enzyme in sleep regulation. When the enzyme activity is inhibited by its specific inhibitor, SeCl4 in vivo, rats can no longer sleep.
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Prostaglandin D2 (PGD2) is the endogenous sleep inducing substance in rats, mice, monkeys and probably in humans. PGD synthase (PGDS), the enzyme that produces PGD2 in the brain, is the key enzyme in sleep regulation. When the enzyme activity is inhibited by its specific inhibitor, SeCl4 in vivo, rats can no longer sleep.
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
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