Results 41 to 50 of about 345,095 (348)

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins[S]

open access: yesJournal of Lipid Research, 2010
Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes.
Caroline Subra   +11 more
doaj  

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

open access: yesAdvanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu   +6 more
wiley   +1 more source

Effects of prostaglandin analogues on aqueous humor outflow pathways.

open access: yesJournal of Ocular Pharmacology and Therapeutics, 2014
Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All treatments, whether surgical or pharmaceutical, are aimed at lowering IOP.
Nelson S. Winkler, M. Fautsch
semanticscholar   +1 more source

Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation

open access: yesAdvanced Healthcare Materials, EarlyView.
Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara   +7 more
wiley   +1 more source

Efficacy and Patient Tolerability of Omidenepag Isopropyl in the Treatment of Glaucoma and Ocular Hypertension

open access: yesClinical Ophthalmology, 2022
Masato Matsuo,1 Yotaro Matsuoka,2 Masaki Tanito1 1Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo City, Shimane, 693-8501, Japan; 2Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Shimane, 690-8506 ...
Matsuo M, Matsuoka Y, Tanito M
doaj  

Enhanced Myogenic Constriction in the SHR Preglomerular Vessels Is Mediated by Thromboxane A2 Synthesis

open access: yesFrontiers in Physiology, 2020
BackgroundSpontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9).
Samera Nademi   +3 more
doaj   +1 more source

Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term.

open access: yesCochrane Database of Systematic Reviews, 2014
BACKGROUND Prostaglandins have been used for induction of labour since the 1960s. This is one of a series of reviews evaluating methods of induction of labour.
Jane Thomas   +3 more
semanticscholar   +1 more source

Ultra‐Fine 3D Bioprinting of Dynamic Hyaluronic Acid Hydrogel for in Vitro Modeling

open access: yesAdvanced Materials, EarlyView.
3D bioprinting merges tissue engineering and additive manufacturing to create biological structures. A bioink is developed by modifying hyaluronic acid, a natural extracellular matrix polymer, with cysteine. Potassium iodide is later added to tune gelation kinetics, enabling fine printing with a 32G needle.
Shima Tavakoli   +3 more
wiley   +1 more source

A metabolome-wide case-control study of african american breast cancer patients

open access: yesBMC Cancer, 2023
Background Breast cancer survivors face long-term sequelae compared to the general population, suggesting altered metabolic profiles after breast cancer.
Jiajun Luo   +8 more
doaj   +1 more source

Nanostructured 316L Stainless Steel Stent Surfaces Improve Corrosion Resistance, and Enhance Endothelization and Hemocompatibility

open access: yesAdvanced Materials Interfaces, EarlyView.
This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan   +2 more
wiley   +1 more source

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