Results 31 to 40 of about 248,083 (296)

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Geisslinger, Gerd, Gerd Geisslinger, Scholich, Klaus, Angioni, Carlo Federico, Klaus Scholich, Laura Popp, Sandra Pierre, Brenneis, Christian, Ovidiu Coste, Claudiu Marian, Marian, Claudiu, Popp, Laura, Coste, Ovidiu, Carlo Angioni, Schmidt, Helmut, Christian Brenneis, Pierre, Sandra, Helmut Schmidt   +17 more
core   +1 more source

EP4 receptor stimulation in combination with core decompression therapy enhanced bone regeneration in a canine model of osteonecrosis of femoral head

Frontiers in Bioengineering and Biotechnology
Core decompression (CD) is a minimally invasive procedure widely used to treat early-stage osteonecrosis of the femoral head (ONFH). However, CD alone often yields suboptimal outcomes in promoting bone regeneration in necrotic lesions, highlighting the ...
Kyoko Hirano, Kyoko Hirano, Takaki Miyagawa, Masahiro Nishida, Haruhiko Akiyama, Haruhiko Akiyama   +5 more
doaj   +1 more source

Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension

Clinical Ophthalmology, 2022
Bridgitte Shen Lee,1 Ranjan Malhotra,2 Kenneth Sall,3 Brittany Mitchell,4 James Peace5 1Vision Optique, Houston, TX, USA; 2Ophthalmology Associates, St. Louis, MO, USA; 3Sall Research Medical Center, Inc., Artesia, CA, USA; 4Medical Affairs North America,
Shen Lee B, Malhotra R, Sall K, Mitchell B, Peace J   +4 more
doaj  

Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry

Metabolites, 2015
Tandem mass spectrometry (MS/MS) with Sequential Window Acquisition of all Theoretical (SWATH) mass spectra generates a comprehensive archive of lipid species within an extract for retrospective, quantitative MS/MS analysis.
Jeevan K. Prasain, Landon Wilson, Hieu D. Hoang, Ray Moore, Michael A. Miller   +4 more
doaj   +1 more source

Gender-typical olfactory regulation of sexual behavior in goldfish

Frontiers in Neuroscience, 2014
It is known that olfaction is essential for the occurrence of sexual behavior in male goldfish. Sex pheromones from ovulatory females elicit male sexual behavior, chasing and sperm releasing act.
Makito eKobayashi
doaj   +1 more source

Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii

Memorias do Instituto Oswaldo Cruz, 2014
Lipid bodies [lipid droplets (LBs)] are lipid-rich organelles involved in lipid metabolism, signalling and inflammation. Recent findings suggest a role for LBs in host response to infection; however, the potential functions of this organelle in ...
Laura Azeredo Miranda Mota, João Roberto Neto, Verônica Gomes Monteiro, Caroliny Samary Silva Lobato, Marco Antonio de Oliveira, Maura da Cunha, Heloisa D’Ávila, Sérgio Henrique Seabra, Patrícia Torres Bozza, Renato Augusto DaMatta   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Research progress on the role of prostaglandins in atopic dermatitis

Pifu-xingbing zhenliaoxue zazhi
Atopic dermatitis (AD) is a chronic inflammatory skin disease mediated by genetic, immune, and environmental factors. Prostaglandins (PGs), as critical lipid mediators, exert complex regulatory roles in AD.
WANG Mingxin, DONG Liping, XIAO Fengli
doaj   +1 more source

Regulation of microsomal prostaglandin E2 synthase by cyclopentenone prostaglandins in colon cancer cells [PDF]

, 2006
Prostaglandin E2 is the major prostaglandin involved in colorectal carcinogenesis. The biosynthesis of prostaglandin E2 is accomplished by several terminal prostaglandin E synthases through catalytical conversion of the cyclooxygenase product ...
Yudina, Yulyana
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source