Results 41 to 50 of about 63,527 (251)

LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes

Journal of Lipid Research, 2011
15-series prostaglandins (PGE2s) and isoprostanes (isoPGE2s) are robust biomarkers of oxidative stress, possess potent biological activity, and may be derived through cyclooxygenase or free radical pathways.
Stephen A. Brose, Brock T. Thuen, Mikhail Y. Golovko   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Novel prostaglandin and isoprostane panel for evaluating Wilson’s Disease

Türk Biyokimya Dergisi
Wilson’s disease (WD) leads to copper accumulation in the liver and brain. It generates oxidative stress, which can damage the liver and central nervous system (CNS). The concentrations of oxidized lipid products, such as prostaglandins and isoprostanes,
Polat Merve Banu, Durukan Bekir Mert, İsrafilov Sabir, Yalçın Çakmaklı Gül, İdilman İlkay S., Dağ Osman, Karçaaltıncaba Muşturay, Sökmensüer Cenk, Elibol Bülent, Balaban Hatice Yasemin, Pınar Aslı   +10 more
doaj   +1 more source

Comparison of the Effects of Estradiol Cream and Vaginal Misoprostol Suppository on Cervical Preparation [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim :One of the methods of preparing the cervix for induction of labor is use of drugs. Use of prostaglandins and estradiol is one of these methods.
jila agah, roya baghani, mohamad hasan rakhshani   +2 more
doaj  

Expression of Oxytocin/Neurophysin I and Oxytocinase in the Equine Conceptus from Day 8 to Day 21 Post-Ovulation

Animals, 2022
Leucyl and cystinyl aminopeptidase (LNPEP/oxytocinase) is an enzyme that metabolizes oxytocin in serum and tissues. The presence of oxytocin/neurophysin I (OXT), oxytocin and LNPEP and their relationship to other genes is unknown in the equine conceptus.
Mariana Diel de Amorim, Claudia Klein, Robert Foster, Lynn Dong, Maria Fernanda Lopez-Rodriguez, Claire Card   +5 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Development of a novel rat long-bone nonunion model and efficacy evaluation of a prostaglandin EP4 selective agonist (AKDS001) combined with iliac bone grafting

Bone & Joint Research
Aims: Nonunion occurs when a fracture fails to heal permanently, often necessitating surgical intervention to stimulate the bone healing response. Current animal models of long-bone nonunion do not adequately replicate human pathological conditions ...
Daisuke Tateiwa, Masahiro Nishida, Joe Kodama, Hiromasa Hirai, Shinichi Nakagawa, Yuichiro Ukon, Kazuhiro Takeyama, Natsumi Yamamori, Kyoko Hirano, Masato Ikuta, Takayuki Kitahara, Takuya Furuichi, Masayuki Bun, Seiji Okada, Takashi Kaito   +14 more
doaj   +1 more source

Effects of supplemental oxytocin or prostaglandin F2α analogue in extended boar semen on piglet productivity of gilts and sows artificially inseminated in summer

Біологія тварин, 2023
We determined the effects of oxytocin (OT) and prostaglandin F2α analogue (PG) added to extended boar semen on the duration of artificial insemination (AI) and reproductive performance of pigs bred in July and August (temperate climate of Central Europe).
T. Schwarz, P. Jaros, R. Tuz, J. Nowicki, S. St. Jules, M. Małopolska, M. Sharan, P. M. Bartlewski   +7 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source