Results 11 to 20 of about 187,978 (260)

Lactones in the Synthesis of Prostaglandins and Prostaglandin Analogs [PDF]

International Journal of Molecular Sciences, 2021
In the total stereo-controlled synthesis of natural prostaglandins (PGs) and their structural analogs, a vast class of compounds and drugs, known as the lactones, are encountered in a few key steps to build the final molecule, as: δ-lactones, γ-lactones, and 1,9-, 1,11-, and 1,15-macrolactones.
Constantin Tănase, Lucia Pintilie, Raluca Elena Tănase   +2 more
openaire   +3 more sources

PROSTAGLANDINS

The Lancet, 1968
Observations from 1930 to 1934 have indicated autopharmacological effects of human seminal fluid. The active principle was shown to be an unsaturated lipid‐soluble acid. After isolation in 1960 of two closely related compounds, the chemical constitution was established.
openaire   +6 more sources

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins[S]

Journal of Lipid Research, 2010
Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes.
Caroline Subra, David Grand, Karine Laulagnier, Alexandre Stella, Gérard Lambeau, Michael Paillasse, Philippe De Medina, Bernard Monsarrat, Bertrand Perret, Sandrine Silvente-Poirot, Marc Poirot, Michel Record   +11 more
doaj   +1 more source

Arg-Vasotocin Directly Activates Isotocin Receptors and Induces COX2 Expression in Ovoviviparous Guppies

Frontiers in Endocrinology, 2021
Oxytocin (OT) is a crucial regulator of reproductive behaviors, including parturition in mammals. Arg-vasopressin (AVP) is a nonapeptide homologous to Arg-vasotocin (AVT) in teleosts that has comparable affinity for the OT receptor. In the present study,
Li Kang Lyu, Jian Shuang Li, Xiao Jie Wang, Yi Jia Yao, Ji Fang Li, Yun Li, Hai Shen Wen, Xin Qi   +7 more
doaj   +1 more source

Effect of prostaglandin A1 in the induction of stress proteins in Aedes albopictus cells

Brazilian Journal of Medical and Biological Research, 1998
Prostaglandins are natural fatty acid derivatives with diverse physiological effects, including immune function and the control of cell growth. While the action of prostaglandins in the induction of stress proteins in vertebrate cells is well documented,
J.A. Barbosa, M.A. Rebello
doaj   +1 more source

Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control

Tropical Medicine and Infectious Disease
Glutathione transferases (GSTs EC 2.5.1.18) are critical components of phase II metabolism, instrumental in xenobiotics’ metabolism. Their primary function involves conjugating glutathione to both endogenous and exogenous toxic compounds, which increases
Lluvia de Carolina Sánchez Pérez, Rafael A. Zubillaga, Ponciano García-Gutiérrez, Abraham Landa   +3 more
doaj   +1 more source

Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study

Frontiers in Veterinary Science
IntroductionIdiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs.
Tomohiro Yonezawa, Tomohiro Yonezawa, Shinya Takenouchi, Tomoki Motegi, Michiyo Miyazaki, Nanae Nagata, Koji Kobayashi, Koji Kobayashi, Masaki Yamada, Takahisa Murata, Takahisa Murata, Takahisa Murata   +11 more
doaj   +1 more source

EP4 receptor stimulation in combination with core decompression therapy enhanced bone regeneration in a canine model of osteonecrosis of femoral head

Frontiers in Bioengineering and Biotechnology
Core decompression (CD) is a minimally invasive procedure widely used to treat early-stage osteonecrosis of the femoral head (ONFH). However, CD alone often yields suboptimal outcomes in promoting bone regeneration in necrotic lesions, highlighting the ...
Kyoko Hirano, Kyoko Hirano, Takaki Miyagawa, Masahiro Nishida, Haruhiko Akiyama, Haruhiko Akiyama   +5 more
doaj   +1 more source

Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension

Clinical Ophthalmology, 2022
Bridgitte Shen Lee,1 Ranjan Malhotra,2 Kenneth Sall,3 Brittany Mitchell,4 James Peace5 1Vision Optique, Houston, TX, USA; 2Ophthalmology Associates, St. Louis, MO, USA; 3Sall Research Medical Center, Inc., Artesia, CA, USA; 4Medical Affairs North America,
Shen Lee B, Malhotra R, Sall K, Mitchell B, Peace J   +4 more
doaj  

Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry

Metabolites, 2015
Tandem mass spectrometry (MS/MS) with Sequential Window Acquisition of all Theoretical (SWATH) mass spectra generates a comprehensive archive of lipid species within an extract for retrospective, quantitative MS/MS analysis.
Jeevan K. Prasain, Landon Wilson, Hieu D. Hoang, Ray Moore, Michael A. Miller   +4 more
doaj   +1 more source