Results 41 to 50 of about 4,872 (106)

Treprostinil: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Treprostinil is a synthetic prostacyclin analogue with a tricyclic benzindene structure that confers markedly enhanced metabolic stability relative to native prostacyclin, enabling delivery by four distinct routes—intravenous, subcutaneous, inhaled, and oral—that together constitute a mainstay of pharmacotherapy for pulmonary arterial ...
Muhammad Sameed, Muhammad Waleed, Veronika Colomy   +2 more
wiley   +1 more source

Urinary Lipid Production Profile of Patients With Food Allergy

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto‐Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata   +10 more
wiley   +1 more source

Cargo Stability of Extracellular Vesicles Derived From Non‐Diseased Sources: Effects of Storage and Handling Conditions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale, membrane‐enclosed particles that transfer proteins, nucleic acids, lipids, and other bioactive molecules between cells. Their cargo‐bearing capacity supports applications in drug delivery, regenerative medicine, and biomarker development, but ex vivo handling can alter vesicle recovery and cargo ...
Khadijeh Abbasi, Mina Mohammadinasr, Roza Motavalli, Narges Arianfar, Attabak Toofani‐Milani, Moein Shirzad, Vahid Hosseini, Masoud Darabi   +7 more
wiley   +1 more source

Prostaglandin E-major urinary metabolite predicts relapse in patients with ulcerative colitis in clinical remission

Prostaglandin E-major urinary metabolite predicts relapse in patients with ulcerative colitis in clinical remission
doctoral 医学系研究科 INTRODUCTION: Prostaglandin E-major urinary metabolite (PGE-MUM) is a novel biomarker reflecting endoscopic activity in ulcerative colitis (UC). However, there are no studies investigating the efficacy of PGE-MUM as a biomarker for predicting relapse. We investigated whether PGE-MUM can predict clinical relapse of UC.
openaire   +3 more sources

P129 USEFULNESS OF PROSTAGLANDIN E-MAJOR URINARY METABOLITE MEASUREMENT FOR THE DIFFERENTIATION BETWEEN CHRONIC ENTEROPATHY ASSOCIATED WITH SLCO2A1 GENE (CEAS) AND CROHN’S DISEASE [PDF]

Inflammatory Bowel Diseases, 2018
Yuichi Matsuno, Junji Umeno, Yuta Fuyuno, Yasuharu Okamoto, Shigeyoshi Yasukawa, Fumihito Hirai, Kenji Watanabe, Naoki Hosoe, Shuji Kochi, Koichi Kurahara, Tsuneyoshi Yao, Takanari Kitazono, Takayuki Matsumoto, Motohiro Esaki   +13 more
openaire   +1 more source

Enhanced <i>in vivo</i> thromboxane biosynthesis in melanoma compared with basal cell carcinoma skin cancers. [PDF]

Skin Health Dis
Petrucci G, Di Stefani A, Rizzi A, Di Nardo L, Del Regno L, Farhoud MA, Peris K, Rocca B.   +7 more
europepmc   +1 more source

Predicting mucosal healing in patients with ulcerative colitis in clinical remission using biomarkers: A single-center prospective pilot study. [PDF]

Medicine (Baltimore)
Kato N, Kusunoki R, Kamada H, Semba S, Teraoka Y, Mizumoto T, Tamaru Y, Hatakeyama T, Yamaguchi A, Kouno H, Yoshida S, Kuwai T.   +11 more
europepmc   +1 more source

Integrated Pharmacokinetics, Pharmacodynamics, and Pharmacometabolomics to Elucidate Guizhi Fuling Capsule's Homeostatic Mechanism Against Acute Dysmenorrhea. [PDF]

Pharmaceuticals (Basel)
Lyu XR, Lin M, Xu ZH, Xu ST, Li X, Lu ZH, Wei TT, Zhang SY, Wang GJ, Peng Y, Sun JG.   +10 more
europepmc   +1 more source

Urinary Metabolomics in Bladder Cancer: A Scoping Review of Current Evidence and Translation Implications. [PDF]

Int J Mol Sci
Carapito Â, Amaro F, Roque AC, Carvalho F, Pinto J, Guedes de Pinho P.   +5 more
europepmc   +1 more source

Urinary prostaglandin E major urinary metabolite in neonates: Gestational age at birth-dependent dynamics and clinical implications

Pediatrics & Neonatology
Yoshihiko Shitara, Atsushi Ito, Kenichiro Konishi, Akinori Ichinose, Takeo Mukai, Takuya Oshima, Hiroshi Mutoh, Kensuke Suzuki, Takayuki Iriyama, Kohei Kashima, Akio Ishiguro, Motohiro Kato, Jun Fujishiro, Naoto Takahashi   +13 more
openaire   +1 more source