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Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited [PDF]
Digestion, 2016 With the development of new therapeutic approaches, the ultimate goal of ulcerative colitis (UC) treatment is not only clinical remission but also mucosal healing. Successful mucosal healing has been associated with a dramatic risk reduction in UC recurrence and colitis-associated cancer development, which are the most critical complications of UC ...
Isao Okayasu +2 more
exaly +3 more sources
Increased Levels of Prostaglandin E−Major Urinary Metabolite (PGE-MUM) in Chronic Fibrosing Interstitial Pneumonia [PDF]
Respiratory Medicine, 2017 Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major urinary metabolite (PGE-MUM) with respect to ...
Isao Okayasu +2 more
exaly +3 more sources
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Journal of Pediatric Surgery, 2019
Early definitive diagnosis of necrotizing enterocolitis (NEC) based on Bell's staging criteria is difficult because there are few observable changes on abdominal imaging and blood chemistry tests at the onset of the disease.To investigate whether prostaglandin E-2 major urinary metabolite (PGE-MUM) can be a useful surrogate marker reflecting the ...
Masaaki Matsuura +2 more
exaly +3 more sources
Early definitive diagnosis of necrotizing enterocolitis (NEC) based on Bell's staging criteria is difficult because there are few observable changes on abdominal imaging and blood chemistry tests at the onset of the disease.To investigate whether prostaglandin E-2 major urinary metabolite (PGE-MUM) can be a useful surrogate marker reflecting the ...
Masaaki Matsuura +2 more
exaly +3 more sources
Prostaglandin E‐major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity
Journal of Pediatric Gastroenterology and Nutrition, 2017ABSTRACTObjectives:Prostaglandin E‐major urinary metabolite (PGE‐MUM) is a useful biomarker for adult ulcerative colitis (UC) activity. In the present study, we evaluated whether PGE‐MUM can also be a biomarker of pediatric UC activity and compared its efficacy in predicting UC activity with that of C‐reactive protein and erythrocyte sedimentation rate.
Shin-Ichiro, Hagiwara +8 more
openaire +2 more sources
Inflammatory Bowel Diseases, 2014
C-reactive protein (CRP) is used as a biomarker of ulcerative colitis (UC) activity, but CRP levels are sometimes insufficient to reflect UC activity. Therefore, a simple noninvasive biomarker assay with sufficient sensitivity and specificity to accurately reflect UC activity is desired.
Yoshinori, Arai +11 more
openaire +2 more sources
C-reactive protein (CRP) is used as a biomarker of ulcerative colitis (UC) activity, but CRP levels are sometimes insufficient to reflect UC activity. Therefore, a simple noninvasive biomarker assay with sufficient sensitivity and specificity to accurately reflect UC activity is desired.
Yoshinori, Arai +11 more
openaire +2 more sources
Prostaglandin E-major urinary metabolites as a new biomarker for acute mesenteric ischemia
Journal of Trauma and Acute Care SurgeryBACKGROUND Acute mesenteric ischemia (AMI) is an emergent vascular disease caused by cessation of the blood supply to the small intestine. Despite advances in the diagnosis, intervention, and surgical procedures, AMI remains a life-threatening condition.
Keisuke, Suzuki +8 more
openaire +2 more sources
Inflammatory Bowel Diseases
Abstract Background The goal of treatment for Crohn’s disease (CD) is to achieve mucosal or transmural healing, and biomarker measurements are useful in monitoring disease activity and guiding treatment.
Takanori Yamada +2 more
exaly +3 more sources
Abstract Background The goal of treatment for Crohn’s disease (CD) is to achieve mucosal or transmural healing, and biomarker measurements are useful in monitoring disease activity and guiding treatment.
Takanori Yamada +2 more
exaly +3 more sources