Results 341 to 350 of about 394,079 (375)
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Prostaglandin prodrugs. 5.1 Prostaglandin E2 ethylene ketal.
Journal of medicinal chemistry, 1977In order to improve the chemical stability of prostaglanding E2 (2), prostaglanding E2 ethylene ketal (1) was prepred by direct ketalization of 2 with ethylene glycol in benzene. To establish a quantitative assessment of 1 as a chemically stable and orally active prodrug of 2, the hydrolysis of 1 to 2 and the subsequent dehydration of 2 to ...
M J, Cho, G L, Bundy, J J, Biermacher
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1995
Prostaglandin E2 is the most common and biologically potent of the primary prostaglandins. It induces contraction of uterine smooth muscle at all stages of pregnancy and is used principally to induce labour or as an abortifacient. It has vasodilator and bronch-odilator properties. It can be given by vaginal, oral and parenteral routes.
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Prostaglandin E2 is the most common and biologically potent of the primary prostaglandins. It induces contraction of uterine smooth muscle at all stages of pregnancy and is used principally to induce labour or as an abortifacient. It has vasodilator and bronch-odilator properties. It can be given by vaginal, oral and parenteral routes.
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Labour induction using buccal prostaglandin E2
Prostaglandins, 1976Prostaglandins may remain in the circulation for some two hours after oral therapy and any resultant hypertonus may be difficult to treat in these circumstances. Buccal administration based on the concept that tablets could be discarded should this occur, has been evaluated in 30 patients.
J W, Scott, I, Craft
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1995
Treatment of plasma samples by high pH (10-11) can be used to convert the major prostaglandin E2 metabolite, 13,14-dihydro-15-keto-prostaglandin E2, and chemically formed dehydrate derivatives to 11-deoxy-13,14-dihydro-15-keto-11 β, 16e-cycloprosta-glandin E2.
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Treatment of plasma samples by high pH (10-11) can be used to convert the major prostaglandin E2 metabolite, 13,14-dihydro-15-keto-prostaglandin E2, and chemically formed dehydrate derivatives to 11-deoxy-13,14-dihydro-15-keto-11 β, 16e-cycloprosta-glandin E2.
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Prostaglandin E2: Evidence for luteolytic effects
Prostaglandins, 1972Abstract Prostaglandin E 2 has been examined in laboratory animals for possible antifertility and luteolytic properties. Daily subcutaneous injections from Days 4–6 into hamsters (once a day) and from Days 4–7 into rats (twice daily) resulted in termination of pregnancy.
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