Results 111 to 120 of about 1,396,386 (296)

Second-Generation Prostaglandin Receptor EP2 Antagonist, TG8-260, with High Potency, Selectivity, Oral Bioavailability, and Anti-Inflammatory Properties. [PDF]

ACS Pharmacol Transl Sci, 2022
Amaradhi R, Mohammed S, Banik A, Franklin R, Dingledine R, Ganesh T.   +5 more
europepmc   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

2-Carba cyclic phosphatidic acid inhibits lipopolysaccharide-induced prostaglandin E2 production in a human macrophage cell line

Biochemistry and Biophysics Reports, 2019
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that contains a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. Using mouse models for multiple sclerosis (cuprizone-induced demyelination
Yuki Shibaike, Mari Gotoh, Chinatsu Ogawa, Shingo Nakajima, Keisuke Yoshikawa, Tetsuyuki Kobayashi, Kimiko Murakami-Murofushi   +6 more
doaj   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism

, 1992
Eicosanoids, in particular prostaglandin E2 (PGE2), are potent inhibitors of a number of immune responses, including lymphocyte proliferation. We have previously shown that fatty acids, especially polyunsaturated fatty acids (PUFA), inhibit mitogen ...
Calder, P.C., Newsholme, E.A., Bevan, S.J.   +2 more
core   +1 more source

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

Scientific Reports, 2017
Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol.
Antje Brüser, Anne Zimmermann, Brenda C. Crews, Gregory Sliwoski, Jens Meiler, Gabriele M. König, Evi Kostenis, Vera Lede, Lawrence J. Marnett, Torsten Schöneberg   +9 more
doaj   +1 more source

Lipopolysaccharide- and Glutamate-Induced Hypothalamic Hydroxyl Radical Elevation and Fever Can Be Suppressed by N-Methyl-D-aspartate-Receptor Antagonists

Journal of Pharmacological Sciences, 2007
The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3 ...
Cheng-Hsing Kao, Ting-Yu Kao, Wu-Tein Huang, Mao-Tsun Lin   +3 more
doaj   +1 more source

IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor. [PDF]

Ann Med Surg (Lond), 2021
Situmorang H, Hestiantoro A, Purbadi S, Flamandita D, Sahlan M.   +4 more
europepmc   +1 more source

Efficacy and Patient Tolerability of Omidenepag Isopropyl in the Treatment of Glaucoma and Ocular Hypertension

Clinical Ophthalmology, 2022
Masato Matsuo,1 Yotaro Matsuoka,2 Masaki Tanito1 1Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo City, Shimane, 693-8501, Japan; 2Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Shimane, 690-8506 ...
Matsuo M, Matsuoka Y, Tanito M
doaj  

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source