Results 1 to 10 of about 674,548 (295)
Prostaglandin E2 receptors as therapeutic targets in renal fibrosis [PDF]
Kidney Research and Clinical Practice, 2022 Prostaglandin E2 (PGE2), a lipid mediator produced by the cyclooxygenase enzyme system, is the main prostaglandin in the kidney. PGE2 is involved in various physiological and pathophysiological processes in the kidney, including renal hemodynamics, water
Henricus A.M. Mutsaers +1 more
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PHARMACOGENOMICS OF PROSTAGLANDIN AND LEUKOTRIENE RECEPTORS [PDF]
Frontiers in Pharmacology, 2016 Individual genetic background together with environmental effects are thought to be behind many human complex diseases. A number of genetic variants, mainly single nucleotide polymorphisms (SNPs), have been shown to be associated with various ...
José Antonio Cornejo-García +8 more
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EP3 is the only prostaglandin E receptor required for lipopolysaccharide-induced fever [PDF]
Brain, Behavior, & Immunity - HealthFever induced by systemic inflammation is mediated by prostaglandin E2 (PGE2), but the identity of the prostaglandin E (EP) receptor subtype responsible for the febrile response remains debated.
Unn Kugelberg +3 more
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Life Science Alliance, 2022 PGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.
Charles H Wallace +5 more
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Nature Communications, 2023 Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However,
Xiuqing Lv +12 more
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Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. [PDF]
PLoS ONE, 2011 Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis,
Josef Anrather +7 more
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Respiratory Research, 2023 Background Pulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by abnormal contraction and remodeling of the pulmonary arterioles, manifested by pulmonary vascular resistance ...
Cheng Zeng +4 more
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Pharmacotherapy of glaucoma in terms of evidence-based medicine
Качественная клиническая практика, 2023 Glaucoma is a disease associated with increased intraocular pressure (IOP). Of the pharmacological agents for treating glaucoma, there are drugs of the first (most effective and safe) and second-line treatment. First-line treatment includes prostaglandin
V. N. Fedorov +6 more
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Putative role of prostaglandin receptor in intracerebral hemorrhage
Frontiers in Neurology, 2012 Each year, approximately 795,000 people experience a new or recurrent stroke. Of all strokes, 84% are ischemic, 13% are intracerebral hemorrhage (ICH) strokes and 3% are subarachnoid hemorrhage (SAH) strokes.
Shekher eMohan +4 more
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Frontiers in Physiology, 2022 Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known anti-viral treatments ...
Willem J. Sander +4 more
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