Results 1 to 10 of about 93,312 (311)
Prostaglandin E2 receptors as therapeutic targets in renal fibrosis [PDF]
Kidney Research and Clinical Practice, 2022 Prostaglandin E2 (PGE2), a lipid mediator produced by the cyclooxygenase enzyme system, is the main prostaglandin in the kidney. PGE2 is involved in various physiological and pathophysiological processes in the kidney, including renal hemodynamics, water
Henricus A.M. Mutsaers +1 more
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PHARMACOGENOMICS OF PROSTAGLANDIN AND LEUKOTRIENE RECEPTORS [PDF]
Frontiers in Pharmacology, 2016 Individual genetic background together with environmental effects are thought to be behind many human complex diseases. A number of genetic variants, mainly single nucleotide polymorphisms (SNPs), have been shown to be associated with various ...
José Antonio Cornejo-García +8 more
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Identification of prostaglandin receptors in human ureters [PDF]
BMC Urology, 2012 Background Prostaglandins play an important role in ureteral obstruction, but the detailed expression profiles of the prostaglandin receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR) remain unknown in the different parts of the human ureter.
Oll Matthias +5 more
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Ligand-based machine learning models to classify active compounds for prostaglandin EP2 receptor [PDF]
Scientific ReportsProstaglandin receptors are pharmacologically validated targets with implications in several medical indications, including glaucoma, cardiac cyanotic disease, pulmonary hypertension, oncology, and various rare diseases.
Paul Dupuyds +7 more
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Life Science Alliance, 2022 PGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.
Charles H Wallace +5 more
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Nature Communications, 2023 Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However,
Xiuqing Lv +12 more
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Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. [PDF]
PLoS ONE, 2011 Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis,
Josef Anrather +7 more
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Prostaglandin E Receptors [PDF]
Journal of Biological Chemistry, 2007 Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction, tissue localization, and regulation of expression ...
Yukihiko, Sugimoto, Shuh, Narumiya
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Prostaglandins and Their Receptors in Insect Biology [PDF]
Frontiers in Endocrinology, 2011 We treat the biological significance of prostaglandins (PGs) and their known receptors in insect biology. PGs and related eicosanoids are oxygenated derivatives of arachidonic acid (AA) and two other C20 polyunsaturated fatty acids. PGs are mostly appreciated in the context of biomedicine, but a growing body of literature indicates the biological ...
Stanley, David, Kim, Yonggyun
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Prostaglandin Receptor Signaling in Disease [PDF]
The Scientific World JOURNAL, 2007 Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2α, PGI2, and TXA2. They are released outside of the cells immediately after synthesis, and exert their actions by binding to a G-protein coupled rhodopsin-type receptor on the
Toshiyuki Matsuoka, Shuh Narumiya
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