Results 11 to 20 of about 674,548 (295)
Prostaglandin E receptors and the kidney
American Journal of Physiology-Renal Physiology, 2000 Prostaglandin E2is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP1, EP2, EP3, and EP4.
Richard M. Breyer, Matthew D. Breyer
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Prostaglandin EP4 receptors: a possible therapeutic target for endometriosis
, 2016 Prostaglandin EP4 receptors: a possible therapeutic target for ...
Garvin, JH +5 more
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Prostaglandin E Receptors [PDF]
Journal of Biological Chemistry, 2007 Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction, tissue localization, and regulation of expression ...
Yukihiko, Sugimoto, Shuh, Narumiya
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Prostaglandins and Their Receptors in Insect Biology [PDF]
Frontiers in Endocrinology, 2011 We treat the biological significance of prostaglandins (PGs) and their known receptors in insect biology. PGs and related eicosanoids are oxygenated derivatives of arachidonic acid (AA) and two other C20 polyunsaturated fatty acids. PGs are mostly appreciated in the context of biomedicine, but a growing body of literature indicates the biological ...
Stanley, David, Kim, Yonggyun
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Prostaglandin Receptor Signaling in Disease [PDF]
The Scientific World JOURNAL, 2007 Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2α, PGI2, and TXA2. They are released outside of the cells immediately after synthesis, and exert their actions by binding to a G-protein coupled rhodopsin-type receptor on the
Toshiyuki Matsuoka, Shuh Narumiya
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Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]
, 2006 Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M. +9 more
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Prostaglandins and prostaglandin receptor antagonism in migraine [PDF]
The Journal of Headache and Pain, 2013 Human models of headache may contribute to understanding of prostaglandins' role in migraine pathogenesis. The current thesis investigated the migraine triggering effect of prostaglandin E2 (PGE2) in migraine patients without aura, the efficacy of a novel EP4 receptor antagonist, BGC20-1531, in prevention of PGE2-induced headache and the ability of ...
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Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]
, 2009 Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Hermann, Patrick C. +6 more
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BMC Gastroenterology, 2022 Background Aberrations in cyclooxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients with colorectal neoplasia (CRN), could hypothetically qualify as predisposing CRN-markers.
Ulrike Ries Feddersen +5 more
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Journal of Allergy and Clinical Immunology: Global, 2023 Background: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. Objective: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to ...
Aiko Oka, MD +8 more
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