Roles of EP Receptors in the Regulation of Fluid Balance and Blood Pressure. [PDF]
Front Endocrinol (Lausanne), 2022 Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure, PGE2 is implicated in sustaining volume and hemodynamics homeostasis.
Wang L, Wu Y, Jia Z, Yu J, Huang S.
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Pharmacological modulation of prostaglandin E2 (PGE2 ) EP receptors improves cardiomyocyte function under hyperglycemic conditions. [PDF]
Physiol Rep, 2022 Type 2 diabetes (T2D) affects >30Â million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the setting of obesity
Bosma KJ +9 more
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Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. [PDF]
Cancer Metastasis Rev, 2011 Prostaglandins are lipid compounds that mediate many physiological effects. Prostaglandin E2 (PGE(2)) is the most abundant prostanoid in the human body, and synthesis of PGE(2) is driven by cyclooxygenase enzymes including COX-2. Both elevated expression of COX-2 and increased PGE(2) levels have been associated with many cancers including breast cancer.
Reader J, Holt D, Fulton A.
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The role of the EP receptors for prostaglandin E2 in skin and skin cancer. [PDF]
Cancer Metastasis Rev, 2011 One of the most common features of exposure of skin to ultraviolet (UV) light is the induction of inflammation, a contributor to tumorigenesis, which is characterized by the synthesis of cytokines, growth factors and arachidonic acid metabolites, including the prostaglandins (PGs).
Rundhaug JE +3 more
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Prostaglandin EP Receptors Involved in Modulating Gastrointestinal Mucosal Integrity
Journal of Pharmacological Sciences, 2010 .: Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the gastrointestinal tract, and E type PGs are most effective in these actions.
Koji Takeuchi +2 more
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The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production. [PDF]
Poult SciOxidative stress and inflammation commonly occur in modern poultry farming, where they are closely linked mechanistically during the progression of disease and adaptation to stressors. This review synthesizes current evidence to outline cyclooxygenase-2 (
Xiao X +12 more
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Gender and task type effects on the neural network of emotional prosody processing. [PDF]
Commun BiolEmotional prosody (EP) processing is vital for social communication. Seed-based functional connectivity has been widely used to probe its neural basis, yet most studies rely on part of predefined regions, introducing uncertainty and bias.
Hu P +8 more
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Prostaglandin E2 receptors as therapeutic targets in renal fibrosis [PDF]
Kidney Research and Clinical Practice, 2022 Prostaglandin E2 (PGE2), a lipid mediator produced by the cyclooxygenase enzyme system, is the main prostaglandin in the kidney. PGE2 is involved in various physiological and pathophysiological processes in the kidney, including renal hemodynamics, water
Henricus A.M. Mutsaers +1 more
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Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. [PDF]
PLoS ONE, 2012 Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail.
Hakima Mechiche +4 more
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